[2-(2,5-Dichloro-pyriMidin-4-ylaMino)-phenyl]-oxo-acetic acid is a pyrimidine derivative and phenyl oxoacetic acid compound with the molecular formula C12H8Cl2N4O3. It is characterized by the presence of two chlorine atoms at the 2,5-positions of the pyrimidine ring and an amino group attached to the phenyl ring. This chemical structure endows it with potential inhibitory activity against dihydrofolate reductase, a key enzyme in the synthesis of DNA and RNA, making it a promising candidate for antifolate-based cancer treatment.
1644503-10-5
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Basic information
- Product Name: [2-(2,5-Dichloro-pyriMidin-4-ylaMino)-phenyl]-oxo-acetic acid
- Synonyms: [2-(2,5-Dichloro-pyriMidin-4-ylaMino)-phenyl]-oxo-acetic acid
- CAS NO:1644503-10-5
- Molecular Formula: C12H7Cl2N3O3
- Molecular Weight: 312.10828
- EINECS: -0
- Product Categories: N/A
- Mol File: 1644503-10-5.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 509.6±50.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.625±0.06 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 2.00±0.54(Predicted)
- CAS DataBase Reference: [2-(2,5-Dichloro-pyriMidin-4-ylaMino)-phenyl]-oxo-acetic acid(CAS DataBase Reference)
- NIST Chemistry Reference: [2-(2,5-Dichloro-pyriMidin-4-ylaMino)-phenyl]-oxo-acetic acid(1644503-10-5)
- EPA Substance Registry System: [2-(2,5-Dichloro-pyriMidin-4-ylaMino)-phenyl]-oxo-acetic acid(1644503-10-5)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1644503-10-5(Hazardous Substances Data)
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1644503-10-5 Usage
Uses
Used in Pharmaceutical Industry:[2-(2,5-Dichloro-pyriMidin-4-ylaMino)-phenyl]-oxo-acetic acid is used as a potential antifolate agent for its ability to inhibit dihydrofolate reductase, an enzyme crucial for the synthesis of DNA and RNA. This inhibition can disrupt the rapid cell division and growth observed in cancer cells, making it a promising candidate for cancer treatment.
Used in Cancer Research:
In the field of cancer research, [2-(2,5-Dichloro-pyriMidin-4-ylaMino)-phenyl]-oxo-acetic acid is utilized for its potential to target and inhibit the activity of dihydrofolate reductase, thereby affecting the proliferation of cancer cells. Its study contributes to the development of novel therapeutic strategies for various types of cancer.
Used in Drug Development:
[2-(2,5-Dichloro-pyriMidin-4-ylaMino)-phenyl]-oxo-acetic acid serves as a key compound in the development of new pharmaceuticals targeting dihydrofolate reductase. Its unique chemical structure and biological activity make it a valuable asset in the creation of innovative drugs for cancer treatment.
Used in Biochemical Studies:
In biochemical research, [2-(2,5-Dichloro-pyriMidin-4-ylaMino)-phenyl]-oxo-acetic acid is employed to study the mechanisms of action and the role of dihydrofolate reductase in cellular processes. Understanding its interaction with the enzyme can provide insights into the development of targeted therapies for various diseases, including cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 1644503-10-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,4,4,5,0 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.Calculate Digit Verification of CAS Registry Number 1644503-10:
(9*1)+(8*6)+(7*4)+(6*4)+(5*5)+(4*0)+(3*3)+(2*1)+(1*0)=145
145 % 10 = 5
So 1644503-10-5 is a valid CAS Registry Number.
1644503-10-5Upstream product
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[2-(2,5-Dichloro-pyriMidin-4-ylaMino)-phenyl]-oxo-acetic acid
