1644539-91-2Relevant academic research and scientific papers
A cooperative N-heterocyclic carbene/chiral phosphate catalysis system for allenolate annulations
Lee, Anna,Scheidt, Karl A.
supporting information, p. 7594 - 7598 (2014/08/05)
The highly enantioselective NHC-catalyzed [3+2] annulation reaction with α,β-alkynals and α-ketoesters has been developed. A new mode of cooperative catalysis involving the combination of a chiral Bronsted acid and a C1-symmetric biaryl saturated-imidazolium precatalyst was required to generate the desired γ-crotonolactones in high yields and levels of enantioselectivity.
