1644563-13-2Relevant academic research and scientific papers
α-C-H functionalization of π-bonds using iron complexes: Catalytic hydroxyalkylation of Alkynes and Alkenes
Wang, Yidong,Zhu, Jin,Durham, Austin C.,Lindberg, Haley,Wang, Yi-Ming
, p. 19594 - 19599 (2019/12/25)
The discovery of catalytic systems based on earth-abundant transition metals for the functionalization of C-H bonds enables streamlined and sustainable solutions to problems in synthetic organic chemistry. In this Communication, we disclose an iron-based catalytic system for the functionalization of propargylic and allylic C-H bonds. Inexpensive and readily available cyclopenta-dienyliron(II) dicarbonyl complexes were employed as catalysts for a novel deprotonative activation mode for C-H functionalization, an approach that allows for the direct union of unsaturated building blocks with aryl aldehydes and other carbonyl electrophiles to deliver a range of unsaturated alcohol coupling products under operationally simple and functional group tolerant reaction conditions.
Copper-catalyzed one-pot trifluoromethylation/aryl migration/carbonyl formation with homopropargylic alcohols
Gao, Pin,Shen, Yong-Wen,Fang, Ran,Hao, Xin-Hua,Qiu, Zi-Hang,Yang, Fan,Yan, Xiao-Biao,Wang, Qiang,Gong, Xiang-Jun,Liu, Xue-Yuan,Liang, Yong-Min
supporting information, p. 7629 - 7633 (2014/08/05)
A novel copper-catalyzed one-pot functionalization of homopropargylic alcohols that involves trifluoromethylation, aryl migration, and formation of a carbonyl moiety has been developed. This reaction constitutes the first direct conversion of homopropargy
