1644612-89-4

Upstream product

• 142779-83-7 5-iodo-2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 1694-31-1 tert-butyl acetoacetate 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 

Downstream Products

• 1644612-90-7 (E)-5-{5'-[4-(diphenylamino)phenyl]-2,2'-bithiophen-5-yl}-6-(2-{5'-[4-(diphenylamino)phenyl]-2,2'-bithiophen-5-yl}vinyl)-2,2-dimethyl-4H-1,3-dioxin-4-one 

Relevant academic research and scientific papers

Rapid and structurally diverse synthesis of multi-substituted β-keto amide derivatives based on a dioxinone scaffold

A sequential diversification approach for the synthesis of various multi-substituted β-keto amide derivatives based on a simple and readily available dioxinone scaffold was developed. The process involves: (1) nucleophilic addition of the scaffold to an aldehyde, and a subsequent one-pot dehydration; (2) palladium-catalysed cross-coupling of the scaffold with either an arylboronic acid pinacol ester, or CO and an aliphatic amine; and (3) nucleophilic addition of either an aliphatic amine or an arylamine, or a hetero-Diels-Alder reaction of isocyanate/isothiocyanate, with an acylketene generated in situ from the dioxinone scaffold. Multi-substituted β-keto amides were synthesized in a sequential four-component coupling process based on a dioxinone scaffold.