1644630-43-2Relevant academic research and scientific papers
Comparison of pyridyl and pyridyl N-oxide groups as acceptor in hydrogen bonding with carboxylic acid
Saraswatula, Viswanadha G.,Bhat, Mukhtar A.,Gurunathan, Pradeep Kumar,Saha, Binoy K.
, p. 4715 - 4721 (2014/06/09)
Competition experiments between pyridyl and pyridyl N-oxide groups have been performed to find out which of these two groups is a better acceptor in hydrogen bonding with the carboxylic acid group. 4,4′-bipyridine N-monoxide, a rigid, conjugated, and linear molecule and 4,4′- trimethylenebipyridine N-monoxide, a flexible, non-conjugated between two aryl groups, and bent molecule, have been used to synthesize complexes with some carboxylic acid containing compounds. The study shows that although the occurrence of pyridyl...acid synthon is more than the corresponding pyridyl N-oxide...acid synthon, based on the distance criterion and energy calculation, the pyridyl N-oxide...acid synthon is slightly stronger than the pyridyl...acid synthon. Solubility studies also show that the pyridyl N-oxide compound may be a better choice as a coformer than the corresponding pyridyl derivative to increase the solubility of carboxylic acid containing compounds.
