164471-64-1

Upstream product

• 4526-07-2 1,4-bis(trimethylsilyl)-1,3-butadiyne 
• 615-43-0 2-iodophenylamine 
• 4526-06-1 trimethylsilyl-1,3-butadiyne 
• 52670-38-9 2-ethynylaniline 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 1436750-30-9 1-(2,2,2-trichloroacteyl)-3-{2-[4-(trimethylsilyl)buta-1,3-diynyl]phenyl}urea 
• 1436751-69-7 1,2-dihydro-1-methylene-2-phenylimidazo[1,5-a]indol-3-one 
• 1436751-59-5 2,3-diphenylpyrimido[1,6-a]indol-1(2H)-one 
• 1436751-45-9 3-phenylpyrimido[1,6-a]indol-1(2H)-one 
• 1436751-04-0 1-phenyl-3-[2-(phenylbuta-1,3-diyn-1-yl)phenyl]urea 
• 1436750-99-0 1-[2-(buta-1,3-diynyl)phenyl]-3-phenylurea 
• 1436750-94-5 1-[2-(buta-1,3-diynyl)phenyl]-3-methylurea 
• 1436750-78-5 1-{2-[4-(trimethylsilyl)buta-1,3-diynyl]phenyl}urea 
• 1436750-74-1 1-[2-(phenylbuta-1,3-diynyl)phenyl]urea 
• 1436750-13-8 1-(2-buta-1,3-diynyl)phenylurea 
• 1436751-74-4 2-ethynyl-1H-indole-1-carboxamide 
• 1043252-33-0 2-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]aniline 
• 1043252-35-2 2-[4-(4-methoxyphenyl)buta-1,3-diyn-1-yl]aniline 
• 1043252-32-9 2-[4-(naphthalen-1-yl)buta-1,3-diyn-1-yl]aniline 

Relevant academic research and scientific papers

Copper-catalyzed tandem reaction between imines and alcohols leading to indoles

A copper-catalyzed tandem reaction between 2-alkynyl-N-arylideneanilines and alcohols is found to produce N-(alkoxybenzyl)indoles in good to high yields. A wide variety of substituted N-(alkoxybenzyl)indole derivatives can be synthesized by utilizing this

A straightforward synthesis of indole and benzofuran derivatives

A new methodology for the synthesis of indole and benzofuran derivatives has been devised. The starting materials, ortho-substituted aryl diynes, have been easily converted into new unsaturated bis-indolyl and bis-benzofuran derivatives and into 2-ethynylindole and 2-ethynylbenzofuran. Both these products have been further elaborated into more complex unsaturated indole-benzofuran and bis-benzofuran derivatives.

Selectivity for Alkynyl or Allenyl Imidamides and Imidates in Copper-Catalyzed Reactions of Terminal 1,3-Diynes and Azides

Copper-catalyzed reactions of terminal 1,3-diynes with electron-deficient azides to generate either 3-alkynyl or 2,3-dienyl imidamides and imidates are described. The selectivity depends on the diyne substituents and the nucleophile that reacts with the ketenimide intermediate generated from the corresponding triazole precursor. Reactions of 1,3-diynes containing a propargylic acetate afford [3]cumulenyl imidamides, while reactions using methanol as the trapping agent selectively generate 2,3-dienyl imidates. Five-membered heterocycles were obtained from 1,3-diynes containing a homopropargylic hydroxyl or amine substituent.

Consecutive gold(I)-catalyzed cyclization reactions of o -(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas: A one-pot synthesis of pyrimido[1,6- a ]indol-1(2 H)-ones and related systems

Treatment of readily available o-(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas such as 1 with the Au(I)-catalyst 11 affords, via a twofold cyclization process, the isomeric pyrimido[1,6-a]indol-1(2H)-one 3 in good yield.

Synthesis of Isocoumarins from o-Iodobenzoic Acid and Terminal Acetylenes Mediated by Palladium Complexes and Zinc Chloride

o-Iodobenzoic acid (1) reacts with various terminal acetylenes (HCCR) in the presence of Pd(PPh3)4, Et3N, and ZnCl2 in DMF to give the corresponding 3-substituted isocoumarins (: R = n-C4H9 (2a); n-C3H7 (3a); CH2OCH3 (4a); C(CH3)2OH (5a); CH2OH (