164518-98-3

Basic information

• Product Name: benzyl 4-(2-oxooxazolidin-3-yl)piperidine-1-carboxylate
• Synonyms: benzyl 4-(2-oxooxazolidin-3-yl)piperidine-1-carboxylate
• CAS NO: 164518-98-3
• Molecular Weight: 0
• Mol File: 164518-98-3.mol

Chemical Properties

• CAS DataBase Reference: benzyl 4-(2-oxooxazolidin-3-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 4-(2-oxooxazolidin-3-yl)piperidine-1-carboxylate(164518-98-3)
• EPA Substance Registry System: benzyl 4-(2-oxooxazolidin-3-yl)piperidine-1-carboxylate(164518-98-3)

Safety Data

• Hazardous Substances Data: 164518-98-3(Hazardous Substances Data)

Upstream product

• 107-07-3 2-chloro-ethanol 
• 220394-91-2 benzyl 4-isocyanatotetrahydro-1(2H)-pyridinecarboxylate 
• 10314-98-4 1-benzyloxycarbonylpiperidine-4-carboxylic acid 
• 10314-99-5 benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate 
• 501-53-1 benzyl chloroformate 

Relevant articles and documents

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: Synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N- (benzyloxycarbonyl)amino)piperidin-1-yl)butanes

(2S)-2-(3-Chlorophenyl)-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-[spiro (2,3-dihydrobenzthiophene-3,4′-piperidin-1′-yl)]butane S-oxide (1b) has been identified as a potent CCR5 antagonist having an IC50 = 10 nM. Herein, structure-activity relationship studies of non-spiro piperidines are described, which led to the discovery of 4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidine derivatives (3-5) as potent CCR5 antagonists.

CYCLIC AMINE MODULATIONS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to cyclic amines of the formula I: STR1 (wherein R 1, R 2, R 3, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.

Therapeutic heterocycles which antagonize neurokinin receptors

Compounds of formula I STR1 wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.