164520-06-3

Usage

Uses

Used in Organic Synthesis:
Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 6-methyl-3-phenyl-1-propylis utilized as a building block in the creation of other organic compounds. Its complex structure and functional groups make it a valuable component in the synthesis of various molecules.
Used in Pharmaceutical Research:
Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione,
6-methyl-3-phenyl-1-propylis also used in pharmaceutical research for its potential biological activities. It may contribute to the development of new drugs, offering a promising avenue for researchers to explore in the search for novel therapeutic agents.
As the specific properties and uses of Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 6-methyl-3-phenyl-1-propylare still being researched and evaluated, its full potential in different industries and applications may not be fully understood at this time. However, its current applications in organic synthesis and pharmaceutical research highlight its importance in the development of new chemical entities and therapeutics.

Upstream product

• 164520-14-3 1-Cyclopentyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione 
• 164520-07-4 1-Butyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione 
• 164520-16-5 1-Isopropyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione 
• 42285-76-7 6-Methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione 
• 598-05-0 di-1-propyl sulfate 

Downstream Products

• 42285-76-7 6-Methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione 

Relevant academic research and scientific papers

General syntheses of 1-alkyltoxoflavin and 8-alkylfervenulin derivatives of biological significance by the regioselective alkylation of reumycin derivatives and the rates of transalkylation from 1-alkyltoxoflavins into nucleophiles

Regioselective alkylations of reumycin derivatives under alkaline conditions with a dialkyl sulfate or alkyl halide in 1,4-dioxane or DMF to provide 1-alkyltoxoflavin or 8-alkylfervenulin derivatives of biological significance, are described. Namely, the primary and secondary alkylations of reumycin derivatives with appropriate dialkyl sulfates or alkyl bromides under alkaline conditions in 1,4-dioxane gave predominantly 1-alkyltoxoflavin derivatives, while the same alkylations in DMF instead of 1,4-dioxane gave predominantly 8-alkylfervenulin derivatives. In the case of tertiary alkylation, the reumycin derivative with 2-bromo-2-methylpropane in both solvents under the same conditions yielded only the 1-alkyltoxoflavin derivative. Moreover, the rates of transalkylation from 1-alkyltoxoflavin derivatives into nucleophiles, e.g. DMF and n-butylamine, are also described. That is, the toxoflavin derivatives possessing a primary alkyl group at the 1-position were easily dealkylated from the 1-position by heating with DMF, whereupon reumycin (i.e., 1-dealkyltoxoflavin, 8-dealkylfervenulin) derivatives were formed. In other words, transalkylation from the toxoflavin derivatives into DMF took place, However, the transalkylation of 1-alkyltoxoflavin derivatives possessing a secondary or tertiary alkyl group at the 1-position was not observed under such conditions. On the other hand, when heating 1-alkyltoxoflavin derivatives with n-butylamine in 1,4-dioxane, the transalkylations were more easily observed even in the case of 1-alkyltoxoflavin derivatives substituted by a tertiary alkyl group.

Facile and general syntheses of 1-alkyltoxoflavin and 8-alkylfervenulin derivatives of biological significance by the regiospecific alkylation of reumycin (1-demethyltoxoflavin, 8-demethylfervenulin) derivatives

Regiospecific alkylation of reumycins (6) under alkaline conditions with a dialkyl sulfate or alkyl halide in dioxane and in DMF to provide 1-alkyltoxoflavins (5) of biological significance and 8-alkylfervenulins (7), respectively, is described.