164530-22-7Relevant academic research and scientific papers
Synthesis of the north 1 unit of the cephalostatin family from hecogenin acetate 1
Kim, Seongkon,Sutton, Scott C.,Guo, Chuangxing,LaCour, Thomas G.,Fuchs
, p. 2056 - 2070 (1999)
Hecogenin acetate (1) was converted to North 1 azidoketone 5 involving several key transformations: (1) conversion of cyclic sulfate 33b to allylic alcohol 40 via Reich iodoso olefination; (2) E-ring annulation via intermolecular oxygen alkylation of high
Chromium [II]-mediated reductive cleavage of a tertiary halide bearing three β-alkoxy groups. Synthesis of the North hexacyclic steroid unit of the cephalostatin family
Fuchs
, p. 2427 - 2430 (2007/10/02)
Transformation of aldehyde 4 to 17nat, a hexacyclic steroid bearing the requisite functionality and spiroketal stereochemistry of the North portion of the cephalostatin family is described. The key reaction involves CrCl2 mediated reductive cle
