164592-86-3

Upstream product

• 82917-27-9 [2S,4R]-2,4-dimethyl-pentanedioic acid monomethyl ester 
• 4098-66-2 2,4-dimethyl-pentanedioic acid dimethyl ester 
• 186448-81-7 Toluene-4-sulfonic acid (E)-(2R,5R)-2-hydroxy-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-enyl ester 
• 186448-86-2 Triisopropyl-((1R,2R,4S)-2-methoxy-4-{(2R,3S)-3-(4-methoxy-benzyloxy)-2-methyl-4-[2-((E)-(R)-1-methyl-3-(R)-oxiranyl-but-2-enyl)-[1,3]dithian-2-yl]-butyl}-cyclohexyloxy)-silane 
• 164592-60-3 C₅₈H₁₀₆O₇S₄Si₂ 
• 164592-80-7 C₅₆H₁₀₀O₆S₄Si₂ 
• 164592-82-9 C₅₇H₁₀₀O₅S₄Si₂ 
• 164592-59-0 (E)-(2S,5R)-1-[2-((1R,3S)-4,4-Dimethoxy-1,3-dimethyl-butyl)-[1,3]dithian-2-yl]-5-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-en-2-ol 
• 164592-58-9 2-((1R,3S)-4,4-Dimethoxy-1,3-dimethyl-butyl)-[1,3]dithiane 
• 164714-14-1 {(1R,2R,4S)-4-[(2R,3S)-4-{2-[(E)-(R)-3-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-methyl-but-2-enyl]-[1,3]dithian-2-yl}-3-(4-methoxy-benzyloxy)-2-methyl-butyl]-2-methoxy-cyclohexyloxy}-triisopropyl-silane 
• 157837-39-3 Methanesulfonic acid (1S,2R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2-methyl-propyl ester 
• 186448-80-6 (E)-(2R,5R)-5-{2-[(2S,3R)-2-(4-Methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-3-methyl-hex-3-ene-1,2-diol 
• 157837-32-6 (2S,3R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butan-2-ol 
• 186448-78-2 (R)-2-Benzenesulfonyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-[1,3]dithian-2-yl-butan-1-one 

Downstream Products

• 164592-92-1 C₇₁H₁₂₅NO₁₂Si₃ 

Relevant academic research and scientific papers

A unified total synthesis of the immunomodulators (-)-rapamycin and (-)-27-demethoxyrapamycin: Construction of the C(21-42) perimeters

A total synthesis of the potent, naturally occurring immunomodulators (-)-rapamycin (1) and (-)-27-demethoxyrapamycin (2) has been achieved via a unified, highly convergent synthetic strategy. Both targets were elaborated from common building blocks A-E,