16462-26-3Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of 4-aminopyrimidine or 4,6-diaminopyrimidine derivatives as beta amyloid cleaving enzyme-1 inhibitors
Xu, Xiufeng,Peng,Wang, Junjie,Xu, Fengrong,Liang, Lei,Wang, Chao,Niu, Yan,Xu, Ping
, p. 926 - 933 (2019/02/19)
A series of novel aminopyrimidine and diaminopyrimidine derivatives were designed and optimized to improve their potency and permeability relative to lead compound 1 (IC50?=?37.4?μM), which was discovered in a previous virtual screening. The po
