164645-57-2

Upstream product

• 159013-58-8 (R)-N₅-[amino-(nitroimino)-methyl]-N₂-(diphenylacetyl)ornithine 
• 100-46-9 benzylamine 
• 543-27-1 isobutyl chloroformate 
• 50913-12-7 (2R)-2-(tert-butoxycarbonylamino)-5-[(N-nitrocarbamimidoyl)amino]pentanoic acid 
• 226218-61-7 succinimidyl 2,2-diphenylacetate 

Relevant academic research and scientific papers

Structure-activity relationships of neuropeptide Y Y1 receptor antagonists related to BIBP 3226

Analogues of BIBP 3226, (R)-N(α)-diphenylacetyl-N-(4-hydroxybenzyl)argininamide, were synthesized and investigated for Y1 antagonism (Ca2+-assay, HEl cells) and binding on Y1, Y2 and Y5 receptors. Replacing the benzylamino by a tetrahydrobenzazepinyl group preserves most of the Y1 activity. Combination with N(G)-phenylpropyl arginine and a N(α)-p-biphenylylacetyl moiety shifted the NPY receptor selectivity towards Y5. (C) 2000 Elsevier Science Ltd. All rights reserved.

AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND THEIR USE IN THE TREATMENT OF OBESITY

Amino acid derivatives, suitable for the treatment of obesity. The following compound is exemplary of the class: (R)-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl) methyl]-argininamide-acetate.