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Product FOB Price Min.Order Supply Ability Supplier
Cas No: 164650-44-6
No Data 1 Gram 300 Kilogram/Month Nantong Noatic Bio-Pharm Technology Co.,Ltd Contact Supplier
High Purity 99% Pharmaceutical Raw Materials Efinaconazole CAS NO.164650-44-6
Cas No: 164650-44-6
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
Efinaconazole manufacturer/supplier
Cas No: 164650-44-6
No Data 1 Gram 1000 Metric Ton/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
Manufacturer high quality Efinaconazole Cas 164650-44-6 with good price
Cas No: 164650-44-6
No Data 1 Kilogram 1000 Kilogram/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Efinaconazole [164650-44-6]
Cas No: 164650-44-6
No Data 1 Kilogram 1 Metric Ton/Month Hangzhou Think Chemical Co. Ltd Contact Supplier
Factory Price API 99% KP 103 164650-44-6 GMP Manufacturer
Cas No: 164650-44-6
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Efinaconazole Manufacturer/High quality/Best price/In stock
Cas No: 164650-44-6
USD $ 1.0-1.0 / Gram 1 Gram 5 Metric Ton/Month Anhui Dexinjia Biopharm Co., Ltd Contact Supplier
Cas No: 164650-44-6
USD $ 5.0-10.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Enke Pharma-tech Co.,Ltd. (Cangzhou, China ) Contact Supplier
Cas No: 164650-44-6
USD $ 2.0-2.0 / Gram 1 Gram 500 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Cas No: 164650-44-6
USD $ 0.9-1.0 / Kilogram 1 Kilogram 1 Metric Ton/Day LIDE PHARMACEUTICALS LIMITED Contact Supplier

164650-44-6 Usage


Different sources of media describe the Description of 164650-44-6 differently. You can refer to the following data:
1. In October 2013, efinaconazole (also known as KP-103) was approved in Canada as a 10% topical solution for the treatment of onychomycosis. Like other azole antifungal agents, efinaconazole acts by disrupting fungal cell membranes through inhibition of sterol 14α-demethylase, an enzyme involved in the biosynthesis of ergosterol, which is a key component of the fungal cell membrane. Efinaconazole has potent antifungal activity against clinical isolates of dermatophytes, including Trichophyton mentagrophyes (MIC80 =0.125 μg/mL) and Trichophyton rubrum (MIC80 =0.25 μg/mL), as well as against Candida and Malassezia species. Unlike other antifungal agents, efinaconazole retains activity in the presence of keratin, indicating that more unbound drug is available at the site of action. Efinaconazole is efficacious in guinea-pig models of fungal infection. Efinaconazole is prepared by reaction of an epoxide intermediate with 4-methylenepiperidine.
2. Efinaconazole is a broad-spectrum triazole antifungal agent with activity against Acremonium, Aspergillus, Candida, Cryptococcus, Epidermophyton, Fusarium, Microsporum, Paecilomyces, Pseudallescheria, Scopulariopsis, Trichophyton, and Trichosporon. It inhibits the growth of T. rubrum and T. mentagrophytes clinical isolates with MIC values ranging from ≤2.0 to 60 ng/ml and of C. albicans isolates with MIC values ranging from ≤0.5 to >250 ng/ml. Efinaconazole inhibits sterol 14α-demethylase, which arrests ergosterol biosynthesis at the fungal membrane. It inhibits ergosterol biosynthesis in T. mentagrophytes and C. albicans with IC50 values of 7.0 and 0.40 ng/ml, respectfully. Topical formulations containing efinaconazole have been used for the treatment of onychomycosis.


Kaken Pharmaceuticals (Japan)


Efinaconazole has been used as:a topical anti-onychomycosis drug to determine its effects on Trichophyton rubrum and Trichophyton interdigitaleas an anti-fungal agent to study its permeability into the nail lysatesas an anti-fungal agent to study its effects on Candida africana and Candida dubliniensis


ChEBI: A member of the class of triazoles that is butan-2-ol which is substituted at positions 1, 2, and 3 by 1,2,4-triazol-1-yl, 2,4-difluorophenyl, and 4-methylenepiperidin-1-yl groups, respectively (the 2R,3R stereoisomer). It is an antifungal drug used for the topical treatment of onychomycosis (a nail infection caused mainly by dermatophytes).

Brand name


Biochem/physiol Actions

Efinaconazole is a triazole antifungal drug approved clinically for the treatment of nail fungus (Onychomycosis). It inhibits sterol biosynthesis by inhibition of cytochrome P450 14α-demethylase, an enzyme in the sterol biosynthesis pathway that leads from lanosterol to ergosterol. Efinaconazole has better nail penetration, so is more effective than other topical agents and as effective as oral medication for nail fungus.


Commercially available (R)-methyl lactate (55) was first converted to THP protected alcohol 57 in 4 steps and 78% yield via morpholino amide 56. Grignard displacement of the morpholine afforded ketone 58 in 81% yield. Next, ketone 58 was epoxidized by means of the Corey ylide followed by ring-opening of the epoxide by triazole which had been activated by exposure to sodium tbutoxide. Finally, subjection to methanesulfonic acid furnished diol 59 in 51% yield as the corresponding mesylate salt. Diol 59 was then converted to epoxide 60 through the use of mesyl chloride and triethylamine in 78% yield and >99% ee. Finally, treatment of epoxide 60 with 4-methylene piperidine–HBr in the presence of lithium hydroxide afforded efinaconazole (VIII) in 87% yield.

Check Digit Verification of cas no

The CAS Registry Mumber 164650-44-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,4,6,5 and 0 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 164650-44:
136 % 10 = 6
So 164650-44-6 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017


1.1 GHS Product identifier

Product name efinaconazole

1.2 Other means of identification

Product number -
Other names Efinaconazole [USAN:INN]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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