164658-43-9Relevant academic research and scientific papers
CYCLIC COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
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Page 18, (2010/02/08)
The invention provides a novel class of cyclic compounds, pharmaceutical compositions comprising such cyclic compounds and methods of using such compounds to treat or prevent diseases and disorders associated with cyclin-dependent kinases (CDKs) activity,
Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof
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, (2008/06/13)
Described are N-phenyl-2-pyrimidineamine derivatives of formula I STR1 wherein R1 is a substituted cyclic radical, the cyclic radical being bonded at a ring carbon atom in each case and being selected from phenyl, pyridyl, pyrazinyl, thiazolyl, pyrimidinyl, pyridazinyl and imidazolyl, and the substituents of the above-mentioned cyclic radical being selected from one or more of the groups halogen, cyano, carbamoyl, --C(=O)--OR3, --C(=O)--R4, --SO2 --N(R5)--R6, --N(R7)--R8, --OR9 and fluorine-substituted lower alkyl, wherein R3, R4, R5, R6, R7, R8 and R9 are each independently of the others hydrogen or lower alkyl that is unsubstituted or substituted by mono- or di-lower alkylamino; and R2 is selected from halogen, cyano, carbamoyl, --C(=O)--OR10, --C(=O)--R11, --SO2 --N(R12)--R13, --N(R14)--R15, --OR16 and fluorine-substituted lower alkyl, wherein R10, R11, R12, R13, R14, R15 and R16 are each independently of the others hydrogen or lower alkyl that is unsubstituted or substituted by mono- or di-lower alkylamino. Those compounds can be used, for example, in the treatment of tumour diseases.
