164668-39-7

Upstream product

• 164668-36-4 (4S,4aR,7R,7aS)-7-Hydroxy-2,2-dimethyl-6-oxo-tetrahydro-furo[3,2-d][1,3]dioxine-4-carbaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 89-67-8 α-D-glucoheptonic γ-lactone 
• 6605-23-8 3,5-O-Isopropylidene-D-glycero-D-gulo-heptono-γ-lactone 
• 6605-22-7 3,5:6,7-bis-O-(1-methylethylidene)-α-D-glucoheptonic γ-lactone 
• 148162-40-7 3,5-O-Isopropylidene-1,1,6-tri-C-phenyl-D-glycero-D-gulo-hexitol 

Downstream Products

• 142955-64-4 (Z)-Methyl 4,6-O-isopropylidene-7-C-phenyl-D-gluco-hept-2-enoate 
• 142955-62-2 (E)-Methyl 4,6-O-isopropylidene-7-C-phenyl-D-gluco-hept-2-enoate 

Relevant academic research and scientific papers

Synthesis and cytotoxic activity of fluorinated analogues of Goniothalamus lactones. Impact of fluorine on oxidative processes

Novel fluorinated analogues of goniothalamin 1 and howiinol A 2 have been prepared from trifluorocrotonate derivatives. Trifluoromethyl goniothalamin (R/S) 4 showed a slightly lower activity than 1, while the trifluoromethyl howiinol A 16 exhibited similar activities on several cell lines in the micromolar range. Unlike (R) goniothalamin and howiinol A, trifluoromethyl parent compounds remained unchanged when submitted to biomimetic oxidative systems.

Enantiospecific Syntheses of (+)-Goniofufurone, (+)-7-epi-Goniofufurone, (+)-Goniobutenolide A, (-)-Goniobutenolide B, (+)-Goniopypyrone, (+)-Altholactone, (+)-Goniotriol, and (+)-7-Acetylgoniotriol

Practical and efficient syntheses of a number of styryl lactones with various structural complexities were accomplished from commercially available and inexpensive D-glycero-D-gulo-heptono-γ-lactone (D-glucoheptonic γ-lactone) (11).Lactone 11 was converte