1647-89-8

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-Fluorophenyl)-4-quinolinecarboxylic acid is used as a precursor in the synthesis of various pharmaceutical compounds for its potential biological activity. Its unique structure allows for the development of new drugs with improved efficacy and selectivity.
Used in Anticancer Applications:
In the field of oncology, 2-(2-Fluorophenyl)-4-quinolinecarboxylic acid is used as a potential anticancer agent. Its pharmacological properties have been investigated for their ability to target and inhibit the growth of cancer cells, making it a promising candidate for the development of novel cancer therapies.
Used in Antibacterial Applications:
2-(2-Fluorophenyl)-4-quinolinecarboxylic acid is also used as a potential antibacterial agent. Its structure and properties have been studied for their ability to target and inhibit the growth of bacteria, offering a potential solution to the growing issue of antibiotic resistance.
Used in Chemical Synthesis:
As a building block in chemical synthesis, 2-(2-Fluorophenyl)-4-quinolinecarboxylic acid is used to create other chemical compounds with potential biological activity. Its unique structure allows for the development of new compounds with diverse applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C16H10FNO2/c17-13-7-3-1-6-11(13)15-9-12(16(19)20)10-5-2-4-8-14(10)18-15/h1-9H,(H,19,20)/p-1

Upstream product

• 445-27-2 2'-Fluoroacetophenone 
• 91-56-5 indole-2,3-dione 
• 127-17-3 2-oxo-propionic acid 
• 446-52-6 2-Fluorobenzaldehyde 
• 62-53-3 aniline 

Downstream Products

• 174636-73-8 2-(2-Fluoro-phenyl)-quinoline-4-carbonyl chloride 
• 148887-67-6 {[2-(2-Fluoro-phenyl)-quinoline-4-carbonyl]-methyl-amino}-acetic acid ethyl ester 
• 148887-80-3 {[2-(2-Fluoro-phenyl)-quinoline-4-carbothioyl]-methyl-amino}-acetic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of Novel Quinoline–Benzoxazolinone Ester Hybrids: In Vitro Anti-Inflammatory Activity and Antibacterial Activity

Abstract: A series of novel quinoline-benzoxazolinone ester hybrids were synthesized characterized and assessed for their in vitro anti-inflammatory and antibacterial activity. The in vitro anti-inflammatory activity was executed using protein denaturation assay, proteinase inhibitory assay and human red blood cell membrane stabilization assay. Most of the compounds exhibited potential anti-inflammatory activity. Compound (2-oxobenzo[d]oxazol-3(2H)-yl)methyl-2-(thiophen-2-yl)quinoline-4-carboxylate showed a better anti-inflammatory activity than the standard drugs diclofenac sodium and indomethacin. Furthermore, antibacterial activities of the synthesized compounds were evaluated using resazurin microtiter assay (REMA) and were compared with a positive drug standard chloramphenicol. The compounds demonstrated moderate to potent antibacterial activity. (2-Oxobenzo[d]oxazol-3(2H)-yl)methyl-2-(3,4-dimethoxyphenyl)quinoline-4-carboxylate and (2-oxobenzo[d]oxazol-3(2H)-yl)methyl-2-(2-chlorophenyl)quinoline-4-carboxylate displayed excellent activity against all bacterial strains in comparison to standard chloramphenicol. Moreover, cytotoxicity was performed on MDCK cells using MTT assay and it was found that none of the synthesized derivatives possessed any cytotoxicity.

Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework

A novel class of potent and selective non-peptide neurokinin-3 (NK-3) receptor antagonists, featuring the 4-quinolinecarboxamide framework, has been designed based upon chemically diverse NK-1 receptor antagonists. The novel compounds 33-76, prompted by chemical modifications of the prototype 4, have been characterized by binding analysis using a membrane preparation of chinese hamster ovary (CHO) cells expressing the human neurokinin-3 receptors (hNK-3-CHO), and clear structure-activity relationships (SARs) have been established. From SARs, (R)-N-[α-(methoxycarbonyl)benzyl]-2- phenylquinoline-4-carboxamide (65, SB 218795, hNK-3-CHO binding K(i) = 13 nM) emerged as one of the most potent compounds of this novel class. Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding K(i) = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding K(i) = >100 μM). In vitro functional studies in rabbit isolated iris sphincter muscle preparation demonstrated that 65 is a competitive antagonist of the contractile response induced by the potent and selective NK-3 receptor agonist senktide with a K(b) = 43 nM. Overall, the data indicate that 65 is a potent and selective hNK-3 receptor antagonist and a useful lead for further chemical optimization.

Synthesis and analgesic-anti-inflammatory activity of certain fluorinated cinchophen analoques

The synthesis of certain fluorinated cinchophen analogues has been achieved.All compounds show analgesic and apparent anti-inflammatory activity comparable to cinchophen and indomethacin but they are toxic at, or close to the 'active' doses.The structure-activity relationship is discussed.

Synthesis and aldose reductase inhibitory activity of N-(quinolinyl thiocarbonyl) glycine derivatives

The onset of diabetic complications may be prevented by the inhibition of aldose reductase.Derivatives of N-(quinolinyl thiocarbonyl) glycine were prepared and their in vitro and ex vivo aldose reductase inhibitory activities were tested on rat lens.The cincophen derivatives were the most potent in vitro with an enzyme inhibition value of 29percent at 10-8 M and 91percent at 10-7 for the N--N-methylglycine compound 10a.This activity was shown to be dependent on the nature of the substituents and seems to be optimal for the acids; esterswerefound to be inactive.No compound have shown ex vivo inhibitory activity.It is concluded that the lack of ex vivo activity is likely due to a poor bioavailability or a bad penetration of the compounds in target tissue (lens). aldose reductase inhibitors / diabetic complications / N-(quinolinyl thiocarbonyl) glycine