1647073-75-3Relevant articles and documents
Copper-mediated ortho-nitration of arene and heteroarene c-h bonds assisted by an 8-aminoquinoline directing group
Liu, Jidan,Zhuang, Shaobo,Gui, Qingwen,Chen, Xiang,Yang, Zhiyong,Tan, Ze
supporting information, p. 732 - 738 (2015/03/18)
A copper-mediated, chelation-assisted ortho C-H bond nitration of benzoic acid derivatives using sodium nitrite as the source of the nitro group has been achieved with the aid of an 8-aminoquinoline directing group. Selective mono- or dinitration can be achieved by simply changing the reaction conditions. The method shows excellent functional group tolerance and provides a novel and straightforward route for the preparation of ortho-nitrated benzoic acids.
