16472-98-3

Upstream product

• 4448-75-3 cycloheptylmethanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 104-15-4 toluene-4-sulfonic acid 
• 7255-72-3 4-chloroaniline p-toluenesulfonate 
• 14034-69-6 Toluene-4-sulfonic acid; compound with 4-methoxy-phenylamine 
• 127660-90-6 N-(Cycloheptylmethyl)-N-phenylamine 
• 14034-57-2 anilinium p-tolylsulfonate 
• 14034-62-9 4-methylanilinium p-toluenesulfonate 

Relevant academic research and scientific papers

Kinetics and mechanism of the aminolysis of cycloalkylmethyl arenesulfonates

Nucleophilic substitution reactions of cycloalkylmethyl arenesulfonates (CmH2n-1 CH2OSO2C6H4Z) with anilines (XC6H4NH2) in methanol at 65.0 °C were studied. The reactivity order (n=4>6>7>5) reflects largely the order of steric effect of the ring size (SEs term) except for n=5, which exhibits the least reactivity. This reversal of the order for n=5 is considered to result from large rate retardation due to polar effect of the ρ*σ* term. Application of the Taft equation to the rate data for n=5 and 6 gives ρ=17·4 and 5=2·3 with correlation coefficient of 0·90. The σ* values for n=4 and 7 are estimated to be - 0·23 and - 0·11, respectively. The positive ρxz values of ca 0·3 are consistent with previous results for the reactions at primary reaction centers.

NRF2 REGULATORS

Provided are aryl analogs，pharmaceutical compositions containing them and their use as NRF2 regulators.