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2-Fluoro-3-oxoandrostan-17-yl acetate is a synthetic chemical compound derived from the androstane steroidal framework. It features a 2-fluoro substitution, which introduces a fluorine atom at the 2-position, and a 3-oxo group, indicating a ketone functional group at the 3-position. The 17-yl acetate denotes an acetate group attached to the 17-position of the androstane structure. 2-fluoro-3-oxoandrostan-17-yl acetate is of interest in medicinal chemistry, particularly in the development of drugs targeting androgen receptors, due to its potential to modulate hormonal activity. The fluorine atom can significantly alter the pharmacokinetic and pharmacodynamic properties of the molecule, potentially enhancing its stability, bioavailability, or receptor binding affinity.

1648-61-9

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1648-61-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1648-61-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,4 and 8 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1648-61:
(6*1)+(5*6)+(4*4)+(3*8)+(2*6)+(1*1)=89
89 % 10 = 9
So 1648-61-9 is a valid CAS Registry Number.

1648-61-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name [(2R,5S,8R,9S,10S,13S,14S,17S)-2-fluoro-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl] acetate

1.2 Other means of identification

Product number -
Other names 17-ethynylandrost-2-ene-17-ol-17-acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1648-61-9 SDS

1648-61-9Relevant academic research and scientific papers

Obtention d'α-fluorocetones par oxydation anodique de derives d'enol.

Laurent, E.,Marquet, B,Tardivel, R.,Thiebault, H.

, p. 955 - 964 (2007/10/02)

To obtain fluoroketones without the use of electrophilic fluorinating reagents, we have carried out the anodic oxidation of enol esters and enol ethers in acetonitrile/Et3N, 3HF solution.With enol esters the main product is a fluoroketone or an acetoxyketone respectively, depending on the structure of the starting compound.The enol ether cation-radicals seemed to be less reactive towards H2F3- ions than the corresponding enol ester ones.

Stable Long-Chain Fluoroxy Compounds and Their Chemistry

Barnette, William E.,Wheland, Robert C.,Middleton, William J.,Rozen, Shlomo

, p. 3698 - 3701 (2007/10/02)

Certain alkali metal salts of long-chain perfluorinated acids were reacted with nitrogen-diluted fluorine to produce oxidative solutions.The reaction conditions can be controlled to afford mainly acyl hypofluorites (RfCOOF) or fluoroxy species fCF2OF and RfCF(OF)2> which have been identified by both chemical reactions and 19F NMR studies.These solutions are useful in electrophilic fluorination reactions and as initiators for the polimerization of some fluorinated monomers.As initiators they produce polymers with fewer reactive end groups when compared with standard methods of initiation.

α-FLUORINATION OF KETONES BY XENON AND IODOBENZENE DIFLUORIDES: A STEREOCHEMICAL EVIDENCE DEMONSTRATING THEIR MECHANISTIC DIFFERENCES

Tsushima, Tadahiko,Kawada, Kenji,Tsuji, Teruji

, p. 1165 - 1168 (2007/10/02)

Xenon difluoride reacts smoothly with various steroid silyl enol ethers in the absence of any acid catalyst to afford stereoselectively α-oriented α-fluoroketones in good yields while iodotoluene difluoride reacts rather sluggishly with these silyl enol ethers to competitively produce β-oriented α-fluoro ketones, elimination and other nucleophilic substitution products.The observed stereochemical contrast clearly suggest an electrophilic and nucleophilic mechanism for these reactions, respectively.

TAMING ELEMENTAL FLUORINE: INDIRECT USE OF FLUORINE FOR THE SYNTHESIS OF α-FLUOROKETONES

Rozen Shlomo,Menahem, Ynon

, p. 19 - 32 (2007/10/02)

Fluorine and sodium trifloroacetate react at -75 deg to produce a variety of fluoroxy-compounds.Although it is possible to direct the reaction towards the formation of CF3COOF or CF3CF2O, mixtures may be used when only the electrophilic fluorine has to be

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