16483-69-5Relevant academic research and scientific papers
Construction of S-CF2/ O-CF2 bonds via inter/intramolecular radical nucleophilic substitution reaction
Deng, Hongmei,Du, Pengcheng,Jiang, Haizhen,Wang, Pingyang,Wang, Wei,Zhang, Jianhua,Zhang, Qian
, (2020)
A facile and efficient method for construction of S-CF2 or O-CF2 bonds through intermolecular radical nucleophilic substitution (SRN1) reaction of 2-bromo-2,2-difluoro-N-phenylacetamide and thiophenols or phenols was developed, which has also been successfully utilized in the intramolecular SRN1 reaction to generate a new O-CF2 bonds for synthesis of biologically important 2,2-difluoro-2H-benzo [1,4]oxazin-3-one. The protocol enables an efficient access to gem-difluoromethylene-containing thioethers or ethers and oxazin heterocycles with good to excellent yields by inter/intramolecular radical nucleophilic substitution reaction under mild reaction conditions.
