1649-27-0

Usage

Uses

Used in Medical Treatments:
5-ANDROSTEN-3BETA-OL-16ALPHA-FLUORO-17-ONE is used as a therapeutic agent for the treatment of hypogonadism, a condition characterized by the underproduction of testosterone, and certain types of breast cancer in women. Its androgenic properties help in managing symptoms associated with these conditions.
Used in Athletic Performance Enhancement:
5-ANDROSTEN-3BETA-OL-16ALPHA-FLUORO-17-ONE is used as a performance-enhancing substance by athletes and bodybuilders. It is favored for its ability to promote muscle growth and increase physical strength, which can provide a competitive edge in sports.
However, it is important to note that the use of 5-ANDROSTEN-3BETA-OL-16ALPHA-FLUORO-17-ONE without medical supervision is associated with significant health risks, including liver toxicity, cardiovascular issues, and potential harm to the reproductive system. Due to its potential for abuse and the serious side effects, it is regulated as a controlled substance in many countries, with strict limitations on its use.

InChI:InChI=1/C19H27FO2/c1-18-7-5-12(21)9-11(18)3-4-13-14(18)6-8-19(2)15(13)10-16(20)17(19)22/h3,12-16,21H,4-10H2,1-2H3

Upstream product

• 19637-35-5 3-tetrahydropyran-2-yloxy-androst-5-en-17-one 
• 32206-51-2 DHEA-2TMS 
• 53-43-0 dehydroepiandrosterone 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR TREATING NEOPLASIA

The invention features compounds, pharmaceutical compositions and methods useful for the treatment of neoplasia. In particular embodiments, the compounds of the invention are useful for the treatment of multidrug resistant neoplasia.

Compounds useful for treating hypertriglyceridemia

The present invention is directed to a method for treating a patient having hypertriglyceridemia comprising administering thereto a compound of the formula:

Power and structure-variable fluorinating agents. The N-fluoropyridinium salt system

The usefulness of the N-fluoropyridinium salt system as a source of fluorinating agents was examined by using substituted or unsubstituted N-fluoropyridinium triflates 1-11, N-fluoropyridinium salts possessing other counteranions 1a-d and 3a, and the counteranion-bound salts, N-fluoropyridinium-2-sulfonates 12 and 13. Electrophilic fluorinating power was found to vary remarkably according to the electronic nature of the ring substituents. This power increased as the electron density of positive nitrogen sites decreased, and this was correlated to the pKa values of the corresponding pyridines. By virtue of this variation, it was possible to fluorinate a wide range of nucleophilic substrates differing in reactivity. It is thus possible to fluorinate aromatics, carbanions, active methylene compounds, enol alkyl or silyl ethers, vinyl acetates, ketene silyl acetals, and olefins through the proper use of salts pentachloro 6 through 2,4,6-trimethyl 2, their power decreasing in this order. All the reactions could be explained on the basis of a one-electron-transfer mechanism. N-Fluoropyridinium salts showed high chemoselectivity in fluorination, the extent depending on the reactive moiety. In consideration of these Findings, selective 9α-fluorination of steroids was carried out by reacting 1 with tris(trimethylsilyl ether) 73 of a triketo steroid. Regio- or stereoselectivity in fluorination was determined by a N-fluoropyridinium salt structure. Steric bulkiness of the N-F surroundings hindered the ortho fluorination of phenols and aniline derivatives, while the capacity for hydrogen bonding on the part of the counteranions prompted this process, and the counteranion-bound salts 12 and 13 underwent this fluorination exclusively or almost so. Both bulky N-fluoropyridinium triflates 2 and 7 preferentially attacked the 6-position of the conjugated vinyl ester of a steroid from the unhindered β-direction to give a thermally unstable 6β-fluoro isomer. On the basis of these results, N-fluoropyridinium salts may be concluded to constitute a system that can serve as a source of the most ideal fluorinating agents for conducting desired selective fluorination through fluorinating capacity or structural alteration.