1649435-49-3

Upstream product

• 1649435-69-7 4-chloro-2-(4-fluorophenyl)-5,6-dihydro[1]benzothiepino[5,4-d]pyrimidine 
• 141-43-5 ethanolamine 
• 88267-23-6 5-Oxo-2,3,4,5-tetrahydro<1>benzothiepin-4-carbonitrile 
• 1649435-39-1 5-amino-2,3-dihydro-1-benzothiepin-4-carbonitrile 

Relevant academic research and scientific papers

Polycyclic N-heterocyclic compounds. Part 82: Synthesis and evaluation of anti-platelet aggregation activity of 2,4-disubstituted 5,6-dihydro[1] benzothiepino[5,4-d]pyrimidine and related compounds

We have synthesized a large number of tricyclic 2-substituted 4-alkylamino-5,6-dihydro[1]benzothiepino[5,4-d]pyrimidines as part of our research to develop new effective anti-platelet drugs. A variety of alkyl and aryl groups were used as substituents at the 2-position. Evaluation of the effects of the newly synthesized compounds on collagen-induced platelet aggregation revealed several promising anti-platelet candidates with potencies superior to aspirin.