1649436-47-4

Upstream product

• 346717-65-5 3-(3-cyanopropylthio)[1]benzothiophene-2-carbonitrile 

Downstream Products

• 1649436-62-3 4-dimethylamino-2-p-tolyl-5,6-dihydro[1]benzothieno[3',2':2,3]thiepino[4,5-d]pyrimidine 
• 1649436-67-8 4-(2-hydroxyethylamino)-2-p-tolyl-5,6-dihydro[1]benzothieno[3',2':2,3]thiepino[4,5-d]pyrimidine 
• 1649436-72-5 4-methoxy-2-p-tolyl-5,6-dihydro[1]benzothieno[3',2':2,3]thiepino[4,5-d]pyrimidine 
• 1649436-77-0 4-ethoxy-2-p-tolyl-5,6-dihydro[1]benzothieno[3',2':2,3]thiepino[4,5-d]pyrimidine 
• 1649436-82-7 4-(2-hydroxyethoxy)-2-p-tolyl-5,6-dihydro[1]benzothieno[3',2':2,3]thiepino[4,5-d]pyrimidine 
• 1649436-87-2 4-(2-hydroxyethylsulfanyl)-2-p-tolyl-5,6-dihydro[1]benzothieno[3',2':2,3]thiepino[4,5-d]pyrimidine 

Relevant academic research and scientific papers

Polycyclic N-heterocyclic compounds. Part 80: Synthesis and evaluation of effects on in vitro pentosidine formation of 5,6-dihydro[1]benzothieno[3′, 2′:2,3]thiepino[4,5-d]pyrimidine and related compounds

Reaction of 3-(3-cyanopropylthio)[1]benzothiophene-2-carbonitrile with tert-BuONa gave 5-amino-1,2-dihydro[1]benzothieno[3,2-d]thieno[2,3-b]pyridine and 5-amino-2,3-dihydro[1]benzothieno[3,2-b]thiepin-4-carbonitrile. The latter compound served as a convenient scaffold for the synthesis of the new heterocycles, [1]benzothieno[3′,2′:2,3]thiepino[4,5-d]pyrimidines. All of our new tetracyclic products were evaluated for in vitro inhibitory activity on the formation of pentosidine, which is one of representative advanced glycation end products. Copyright