16495-80-0Relevant academic research and scientific papers
One-step synthesis of 4,5-disubstituted pyrimidines using commercially available and inexpensive reagents
Baran, Phil S.,Shenvi, Ryan A.,Nguyen, Steven A.
, p. 581 - 586 (2008/02/02)
4,5-Disubstituted pyrimidines are synthesized from the corresponding ketone in one-step using inexpensive reagents (formamidine acetate, n-propanol, heat). Contrasted to other methods, this process appears quite amenable to large-scale use in industrial settings.
THE NITRATION OF PHENYLPYRIMIDINES
Adams, David,Dosanjh, Mohinder,Hurst, Derek T.
, p. 1989 - 1993 (2007/10/02)
The nitration of 4-phenylpyrimidine using nitric acid/sulphuric acid at 0 deg C has been shown to give 4-o-nitrophenylpyrimidine and 4-m-nitro-phenylpyrimidine in the ratio of 4:6.Under similar conditions 5-bromo-2-phenylpyrimidine has given 5-bromo-2o-nitrophenyl and 5-bromo-2-m-nitrophenylpyrimidine in the ratio of 3:7 and 5-chloro-2-phenylpyrimidine has given the 2-o-nitrophenyl and the 2-m-nitrophenyl isomers in the ratio of 3.5:6.5.
