1649975-45-0Relevant academic research and scientific papers
Novel isoxazoline ligand with ferrocene backbone: Preparation and application in Heck reaction with water as solvent
Yu, Shuyan,Zhang, Zhiqin,Yu, Zhiyu,Shang, Yongjia
, p. 657 - 660 (2014)
Two novel isoxazoline N,N-bidentate ligands with ferrocene backbone have been synthesized and employed for the palladium-catalyzed Heck coupling reaction. Among them, 1,3-bis-(5-ferrocenylisoxazoline-3-yl)benzene was found to be thermally stable and a highly effective ligand for Heck coupling reaction in neat water without N2 protection, affording the desired coupling products in good to excellent yield with high diastereoselectivity. The developed catalytic system was also well workable for 1,2-disubstituted alkenes, which were less involved in the Heck reaction for its larger steric hindrance. Copyright
