165108-45-2Relevant academic research and scientific papers
Avermectins and flea control: Structure-activity relationships and the selection of selamectin for development as an endectocide for companion animals
Banks,Bishop,Evans,Gibson,Goudie,Gration,Pacey,Perry,Witty
, p. 2017 - 2025 (2000)
Evaluation of a wide range of avermectin derivatives for flea activity in an in vitro feeding screen using the cat flea, Ctenocephalides felis, revealed a narrow structure-activity relationship (SAR) with activity surprisingly associated with monosaccharides and especially their C-5-oximes. We discovered commercially exploitable flea activity in a single compound, selamectin 33, which also possessed the necessary antiparasitic spectrum and margin of safety for development as a broad-spectrum companion animal endectocide. Copyright (C) 2000 Elsevier Science Ltd.
