16516-67-9

Basic information

• Product Name: 7-BROMO-3,4-DIHYDROISOQUINOLINE HYDROCHLORIDE
• Synonyms: 7-BROMO-3,4-DIHYDROISOQUINOLINE HYDROCHLORIDE
• CAS NO: 16516-67-9
• Molecular Formula: C9H9BrClN
• Molecular Weight: 246.53146
• Mol File: 16516-67-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 201-202.5℃
• Appearance: /
• CAS DataBase Reference: 7-BROMO-3,4-DIHYDROISOQUINOLINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMO-3,4-DIHYDROISOQUINOLINE HYDROCHLORIDE(16516-67-9)
• EPA Substance Registry System: 7-BROMO-3,4-DIHYDROISOQUINOLINE HYDROCHLORIDE(16516-67-9)

Safety Data

• Hazardous Substances Data: 16516-67-9(Hazardous Substances Data)

Usage

General Description

7-BROMO-3,4-DIHYDROISOQUINOLINE HYDROCHLORIDE is a chemical compound with the molecular formula C9H10BrClN. It is a derivative of isoquinoline and contains a bromine atom. 7-BROMO-3,4-DIHYDROISOQUINOLINE HYDROCHLORIDE is commonly used in organic synthesis for the preparation of various pharmaceuticals and other organic compounds. It is typically utilized as a reagent in chemical reactions to introduce the 7-bromo-3,4-dihydroisoquinoline moiety into target molecules. Additionally, the hydrochloride salt form of this compound is often favored for its stability and ease of handling in chemical reactions. Overall, 7-BROMO-3,4-DIHYDROISOQUINOLINE HYDROCHLORIDE is an important building block in organic chemistry and is widely used in the pharmaceutical and chemical industries.

Downstream Products

• 17680-55-6 7-bromo-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion

Compositions comprising a lipid lowering agent selected from cholesterol biosynthesis inhibitors, bile acid sequestrants, fibrates, cholesterol absorption inhibitors, and niacin; and an inhibitor of microsomal triglyceride transfer protein for treating atherosclerosis, obesity and related diseases.

Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and their use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion

Compounds of formula (I), STR1 wherin X is CH2, CO, CS or SO2 ; Y is selected from: a direct link, aliphatic hydrocarbylene radicals having up to 20 carbon atoms, which radical may be mono-substituted by hydroxy, (C1 -C10)alkoxy, (C1 -C10)acyl, (C1 -C10)acyloxy, or (C6 -C10)aryl, NH, and O, provided that if X is CH2,Y is a direct link; Z is selected from the following groups: (1) H, halo, cyano, (2) hydroxy, (C1 -C10)alkoxy, (C1 -C10)a1kylthio, (C1 -C10)acyl, thiophenylcaronyl (C1 -C10)alkoxycarbonyl, (3) (C1 -C10)aklkyammo, di(C1 -C10)alylamino, (C6 -C10)aryl(C1 -C10)alkylamino, provided that Y is not O or NH, (4) unsubstituted vinyl, (C6 -C10)aryl, (C3 -C8)cycloalkyl and fused benz derivatives thereof, (C7 -C10)polycycloalkyl, (C4 -C8)cycloalkenyl, (C7 -C10)polycycloalkenyl, (5) (C6 -C10)aryloxy, (C6 -C10)aryltio, (C6 -C10)aryl(C1 -C10)alkoxy, (C6 -C10)aryl(C1 -C10)alkylthio, (C3 -C8)cycloalkyloxy, (C4 -C8)cycloalkenyloxy, (6) heterocyclyl sclected from the group consisting of monocyclic radicals and fused polycycuic radicals, wherein said radicals contain a total of from 5 to 14 ring atoms, wherein said radicals contain a total of from 1 to 4 ring heteroatoms independently selocted from oxygen, nitrogen, and sulfur, and wherein the individual rings of said radicals may be independendy satated, partally unsaturated, or aromatic, provided that if X is CH2, Z is H or is selected from groups (4) and (6), wherein, when Z contains one or more rings, said rings may each independently bear 0 to 4 substituents independently selected from halo, hydroxy, cyano, nitro, oxo, thioxo, aminosulfonyl, phenyl phenoxy, phenylthio, halophenylthio, benzyl, benzyloxy, (C1 -C10)alkyl, (C1 -C10)alkoxy, (C1 -C10)alkoxycarbonyl, (C1 -C10)althyltio, (C1 -C10)altylamino, (C1 -C10)alkylaminocarbonyl, di(C1 -C10)alkylamino, di(C1 -C10)alkylaminocarbonyl, di(C1 -C10)alkyo(C1 -C10)alkoxy, (C1 -C3)perfluoroalkyl, (C1 -C3)perfluoroalkoxy, (C1 -C10)acyl, (C1 -C10)acyloxy, (C1 -C10)acyloxy(C1 -C10)alkyl, and pyrrolidinyl; and pharmaceutically acceptable salts thereof.