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165253-31-6 Usage


(TETRAHYDROFURAN-3-YL)METHANAMINE is an organic compound that serves as a crucial intermediate in the chemical synthesis process. It is characterized by its unique molecular structure, which includes a tetrahydrofuran ring and an amine group attached to a methylene bridge. (TETRAHYDROFURAN-3-YL)METHANAMINE is known for its role in the creation of various chemical products, particularly in the agricultural and pharmaceutical industries.


Used in Agricultural Industry:
(TETRAHYDROFURAN-3-YL)METHANAMINE is used as a synthetic intermediate for the production of Dinoteturan (D482100), a neonicotinoid insecticide. This insecticide is effective in controlling a wide range of pests that damage crops, making it a valuable component in modern agriculture. Its use contributes to increased crop yields and reduced reliance on less environmentally friendly pest control methods.
Used in Pharmaceutical Industry:
While the provided materials do not explicitly mention any pharmaceutical applications for (TETRAHYDROFURAN-3-YL)METHANAMINE, its role as a synthetic intermediate suggests that it may be involved in the development of other pharmaceutical products. Given its structural properties, it could potentially be used in the synthesis of various drugs, including those with applications in treating diseases or conditions that require targeted drug delivery or specific molecular interactions. Further research and development in this area could reveal additional uses for this compound within the pharmaceutical industry.

Flammability and Explosibility



Tetrahydrofuran-3-yl)methanamine,has been achieved through Michael addition reaction of nitromethane to diethyl maleate in 6 steps with 45.5% total yield.

Check Digit Verification of cas no

The CAS Registry Mumber 165253-31-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,5,2,5 and 3 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 165253-31:
126 % 10 = 6
So 165253-31-6 is a valid CAS Registry Number.

165253-31-6 Well-known Company Product Price

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  • Aldrich

  • (736759)  3-(Aminomethyl)tetrahydrofuran  95%

  • 165253-31-6

  • 736759-250MG

  • 1,304.55CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017


1.1 GHS Product identifier

Product name (Tetrahydrofuran-3-yl)methanamine

1.2 Other means of identification

Product number -
Other names oxolan-3-ylmethanamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:165253-31-6 SDS

165253-31-6Synthetic route





With hydrogen In tert-butyl alcohol at 50 - 55℃; under 1125.11 Torr; for 6h; Solvent; Temperature; Pressure;93%
With palladium on activated charcoal; hydrogen In isopropyl alcohol at 70℃; under 7500.75 - 30003 Torr; for 5h; Reagent/catalyst; Solvent; Temperature; Pressure; Autoclave;92%
With ammonium hydroxide; hydrogen at 100℃; under 7500.75 Torr; for 4h; Autoclave;85%
With ammonium hydroxide; hydrogen at 110℃; under 18751.9 Torr; for 5h; Autoclave;62%
With hydrogen; nickel In tert-butyl alcohol at 50℃; under 380.026 Torr; for 10h; Autoclave;95 g




With hydrogen In methanol at 20℃; under 15001.5 Torr; for 2h; Reagent/catalyst; Pressure;99.4%
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 6h;99%
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 750.075 Torr; for 2h;95%




With ammonia; hydrogen In methanol at 60℃; under 30003 Torr; for 12h; Pressure; Reagent/catalyst; Temperature;99.5%
With hydrogen In methanol at 60℃; under 26252.6 Torr; for 8.5h; Time; Autoclave; Inert atmosphere; Large scale;98.2%
With hydroxyapatite; ammonia; hydrogen In ethanol at 60℃; under 750.075 - 7500.75 Torr; for 3h; Autoclave; Large scale;95%

165253-31-6Relevant articles and documents

Chemoselective and Tandem Reduction of Arenes Using a Metal–Organic Framework-Supported Single-Site Cobalt Catalyst

Akhtar, Naved,Begum, Wahida,Chauhan, Manav,Manna, Kuntal,Newar, Rajashree,Rawat, Manhar Singh

supporting information, (2022/01/19)

The development of heterogeneous, chemoselective, and tandem catalytic systems using abundant metals is vital for the sustainable synthesis of fine and commodity chemicals. We report a robust and recyclable single-site cobalt-hydride catalyst based on a porous aluminum metal–organic framework (DUT-5 MOF) for chemoselective hydrogenation of arenes. The DUT-5 node-supported cobalt(II) hydride (DUT-5-CoH) is a versatile solid catalyst for chemoselective hydrogenation of a range of nonpolar and polar arenes, including heteroarenes such as pyridines, quinolines, isoquinolines, indoles, and furans to afford cycloalkanes and saturated heterocycles in excellent yields. DUT-5-CoH exhibited excellent functional group tolerance and could be reusable at least five times without decreased activity. The same MOF-Co catalyst was also efficient for tandem hydrogenation–hydrodeoxygenation of aryl carbonyl compounds, including biomass-derived platform molecules such as furfural and hydroxymethylfurfural to cycloalkanes. In the case of hydrogenation of cumene, our spectroscopic, kinetic, and density functional theory (DFT) studies suggest the insertion of a trisubstituted alkene intermediate into the Co–H bond occurring in the turnover limiting step. Our work highlights the potential of MOF-supported single-site base–metal catalysts for sustainable and environment-friendly industrial production of chemicals and biofuels.

Synthesis method for 3-aminomethyl tetrahydrofuran


Paragraph 0054; 0058; 0061; 0065-0066; 0070-0071; 0075, (2020/07/14)

The invention provides a synthetic method for 3-aminomethyl tetrahydrofuran. A target product, namely the 3-aminomethyl tetrahydrofuran is prepared by taking 2,5-dihydrofuran as an initial raw material. In the whole synthesis process, the synthesis method has the advantages of green and environmentally-friendly used raw materials, mild and conveniently-controllable reaction conditions, safe production, low risk, simple process, high yield, and more applicability to industrial production.

3-aminomethyl tetrahydrofuran preparation method


Paragraph 0060-0068, (2020/01/12)

The invention provides a 3-aminomethyl tetrahydrofuran preparation method, which comprises: carrying out a condensation reaction by using tetrahydrofuran-3-one and nitromethane as raw materials to obtain 3-nitromethylene tetrahydrofuran, and carrying out catalytic hydrogenation reduction to obtain 3-aminomethyl tetrahydrofuran. According to the invention, the method has advantages of cheap and easily available raw materials, good stability, low cost, simple preparation steps, safe and simple operation, easy reaction achieving, little wastewater generation, environmental protection, few side reactions, high reaction selectivity, good atom economy, high product purity and high yield, and is suitable for industrial production.

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