165280-28-4

Basic information

• Product Name: 3-p-tolyl-1H-cinnolin-4-one
• CAS NO: 165280-28-4
• Molecular Weight: 236.273
• Mol File: 165280-28-4.mol

Chemical Properties

• CAS DataBase Reference: 3-p-tolyl-1H-cinnolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-p-tolyl-1H-cinnolin-4-one(165280-28-4)
• EPA Substance Registry System: 3-p-tolyl-1H-cinnolin-4-one(165280-28-4)

Safety Data

• Hazardous Substances Data: 165280-28-4(Hazardous Substances Data)

Upstream product

• 124643-45-4 2-(p-tolylethynyl)aniline 

Relevant articles and documents

A convenient and efficient protocol for the synthesis of 4(1H)-cinnolones, 1,4-dihydrocinnolines, and cinnolines in aqueous medium: Application for detection of nitrite ions

3-Aryl/alkyl-4(1H)-cinnolones are obtained in one step from 2-aryl/alkylethynyl aniline by reaction with sodium nitrite and dilute hydrochloric acid via Richter cyclization. The alkyl cinnolones on reduction with Sn/HCl furnish 1,4-dihydro-3-alkylcinnolin

Facile cyclization of 2-arylethynyl aniline to 4(1H)-cinnolones: A new chemodosimeter for nitrite ions

2-Arylethynyl anilines undergo very fast reaction (5 min) with nitrite ions in aqueous acidic media to produce 4(1H)-cinnolones which exhibit yellow color and UV absorbance at 391 nm. This reaction is irreversible and has been successfully tested for the