1653-85-6Relevant academic research and scientific papers
Study on self-assembling molecular complexes through hydrogen bonding
Zhang, Ruifeng,Zheng, Haipeng,Shen, Jiacong
, p. 103 - 108 (1998)
A self-complementary hydrogen-bonding recognition unit-2,5-bis(alkylamino)-1,4-benzoquinone has been synthesized and studied. The formation of hydrogen bond in both solid and solution state has been further investigated by means of FTIR, 1H NMR and UV-visible spectra, as well as X-ray diffraction. It can be concluded from the obtained results that the molecular complexes of this kind of compounds have a ribbon-like backbone which plays an important role in keeping the layer supramolecular structure.
Facile synthesis and spectral characterization of 2, 5-bis (cyclohexylamino)-1, 4-benzoquinone polymorphs from methyl and?ethyl protocatechuic aldehydes
Asha,Mohan, A. Sheena,Suma,Sudarsanakumar,Kurup, M.R. Prathapachandra
, p. 299 - 308 (2017)
Two polymorphs of 2,5-bis(cyclohexylamino)-1,4-benzoquinone (BCBQI&BCBQII) are synthesized by an efficient alternate method which includes the oxidation of an aromatic aldehyde to benzoquinone moiety followed by its nucleophilic substitution in a single pot. The synthesized polymorphs have been characterized and distinguished by spectral and single crystal X-ray diffraction methods. A possible mechanism for the conversion is also suggested.
Synthesis, biological evaluation, and molecular docking studies of 2,5-substituted-1,4-benzoquinone as novel urease inhibitors
You, Zhong-Lu,Xian, Dong-Mei,Zhang, Mei,Cheng, Xiao-Shan,Li, Xiao-Fang
experimental part, p. 4889 - 4894 (2012/09/21)
A series of 2,5-substituted-1,4-benzoquinone (1-6) were prepared and structurally characterized by elemental analysis, IR spectra, 1H and 13C NMR spectra, and single crystal X-ray determination. The urease inhibitory activities of the compounds against H. pylori urease were studied. Among the compounds, 2,5-bis(2-morpholin-4-ylethylamino)-[1,4]benzoquinone (2) shows the most effective activity with IC50 value of 27.30 ± 2.17 μM. Docking simulation was performed to insert compound 2 into the crystal structure of H. pylori urease at the active site to determine the probable binding mode. As a result, compound 2 may be used as a potential urease inhibitor.
Synthesis and biological evaluation of 2,5-bis(alkylamino)-1,4- benzoquinones
Barbosa, Luiz Claudio Almeida,Pereira, Ulisses Alves,Maltha, Celia Regina Alvares,Teixeira, Robson Ricardo,Valente, Vania Maria Moreira,Ferreira, Jose Roberto Oliveira,Costa-Lotufo, Leticia Veras,Moraes, Manoel Odorico,Pessoa, Claudia
experimental part, p. 5629 - 5643 (2010/12/24)
A series of twelve 2,5-bis(alkylamino)-1,4-benzoquinones were prepared in yields ranging from 9-58% via the reaction between p-benzoquinone and various amines. The structures of the synthesized compounds were confirmed by IR, 1H- and 13/s
Structure-activity studies on therapeutic potential of thymoquinone analogs in pancreatic cancer
Banerjee, Sanjeev,Azmi, Asfar S.,Padhye, Subhash,Singh, Marjit W.,Baruah, Jubaraj B.,Philip, Philip A.,Sarkar, Fazlul H.,Mohammad, Ramzi M.
scheme or table, p. 1146 - 1158 (2011/03/21)
Purpose: Pancreatic cancer (PC) is one of the deadliest of all tumors. Previously, we were the first to show that Thymoquinone (TQ) derived from black seed (Nigella sativa) oil has anti-tumor activity against PC. However, the concentration of TQ required
Synthesis of 2,5-Diaminoquinones by one-pot copper-catalyzed aerobic oxidation of hydroquinones and addition reaction of amines
Kim, Sungjin,Kim, Daehwan,Park, Jaiwook
experimental part, p. 2573 - 2578 (2009/12/29)
The aerobic oxidation of various hydroquinones was achieved by using copper nanoparticles entrapped in aluminum oxyhydroxide [Cu/ AlO(OH)] at room temperature. Furthermore, 2,5diamino-1,4-benzoquinones were synthesized directly from hydroquinone and amines by a one-pot procedure consisting of the copper-catalyzed aerobic oxidation of hydroquinones and the double addition of amines to the resulting quinones.
