165456-81-5Relevant articles and documents
LAMIVUDINE : ZIDOVUDINE : WATER 1 : 1 : 1 COCRYSTAL
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Page/Page column 12, (2009/10/22)
Co-crystal of lamivudine with zidovudine comprising one molecule each of lamivudine, zidovudine and water; having distinct X-ray diffraction peaks at 2θ of 9.57, 11.45, 13.68, 15.57, 16.49, 18.35, 18.82, 20.45, 22.18, 22.78, 24.52, 24.99, 26.36, 26.55, 26.58 ± 0.2°. Process for preparation of co-crystal of lamivudine with zidovudine comprising of trituration of equimolar quantities of Lamivudine and zidovudine in presence of water at ambient temperature, optionally adding organic solvent during trituration, and drying the product. Process for preparation of co-crystal of lamivudine with zidovudine comprising stirring equimolar quantities of lamivudine and zidovudine in an organic solvent in presence of water at ambient temperature, evaporating solvents of the solution, allowing crystallization of product with optional seeding, isolating co-crystals and drying. Pharmaceutical composition comprising therapeutically effective amount of co-crystals of lamivudine, zidovudine. Use of therapeutically effective amount of co-crystal Zidovudine, Lamivudine for manufacture of medicament for treatment of HIV infections of humans.
