1654774-17-0 Usage
Uses
Used in Organic Synthesis:
2-(p-tolyl)propan-2-aminium chloride is used as a reagent in organic synthesis for its ability to facilitate specific chemical reactions, contributing to the formation of desired products in the synthesis of complex organic molecules.
Used in Chemical Reactions:
In the realm of chemical reactions, 2-(p-tolyl)propan-2-aminium chloride serves as a crucial component, often acting as a catalyst or intermediate that aids in achieving the desired transformation of reactants to products.
Used in Pharmaceutical Development:
2-(p-tolyl)propan-2-aminium chloride is used as a starting material or intermediate in the development of pharmaceuticals, leveraging its potential pharmacological properties. Its analgesic and antitussive effects make it a candidate for the treatment of pain and cough suppression, respectively.
Used in Research:
In academic and industrial research settings, 2-(p-tolyl)propan-2-aminium chloride is utilized as a subject of study to explore its chemical properties, reactivity, and potential applications in new areas of chemistry and medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 1654774-17-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,5,4,7,7 and 4 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1654774-17:
(9*1)+(8*6)+(7*5)+(6*4)+(5*7)+(4*7)+(3*4)+(2*1)+(1*7)=200
200 % 10 = 0
So 1654774-17-0 is a valid CAS Registry Number.
1654774-17-0Relevant articles and documents
One-Pot Synthesis of Primary and Secondary Aliphatic Amines via Mild and Selective sp3 C?H Imination
Comito, Robert J.,Ghosh, Subrata K.,Hu, Mengnan
supporting information, p. 17601 - 17608 (2021/11/03)
The direct replacement of sp3 C?H bonds with simple amine units (?NH2) remains synthetically challenging, although primary aliphatic amines are ubiquitous in medicinal chemistry and natural product synthesis. We report a mild and selective protocol for preparing primary and secondary aliphatic amines in a single pot, based on intermolecular sp3 C?H imination. The first C?H imination of diverse alkanes, this method shows useful site-selectivity within substrates bearing multiple sp3 C?H bonds. Furthermore, this reaction tolerates polar functional groups relevant for complex molecule synthesis, highlighted in the synthesis of amine pharmaceuticals and amination of natural products. We characterize a unique C?H imination mechanism based on radical rebound to an iminyl radical, supported by kinetic isotope effects, stereoablation, resubmission, and computational modeling. This work constitutes a selective method for complex amine synthesis and a new mechanistic platform for C?H amination.
