165538-40-9 Usage
Uses
Used in Pharmaceutical Industry:
Terutroban is used as an anti-platelet therapy for patients with ischemic stroke or transient ischemic attack. It functions by blocking the effect of TXA2 on platelets, as well as inhibiting other ligands such as prostaglandin endoperoxides and isoprostanes.
Used in Research and Development:
Terutroban is used in the research process of anti-coagulant drugs in preventing and controlling cerebral stroke. Its long-acting properties and ability to inhibit TP receptor-mediated actions make it a promising candidate for further investigation and development in the field of thrombosis and atherosclerosis treatment.
in vitro
s18886 was identified as the active isomer of the potent tp receptor antagonist s18204. s18886 was also found to be a selective antagonist of thromboxaneprostaglandin receptors in platelets and in the vessel wall [1].
in vivo
in a previous animal study, it was found that s18886 treatment could reduce the portal pressure in both animal models without producing significant changes in portal blood flow, indicating a reduction in hepatic vascular resistance. s18886 could not significantly change arterial pressure in ccl4 -cirrhotic rats but could significantly decrease it in bdl-cirrhotic rats [2].
IC 50
16.4 nm for tp receptor
references
[1] cimetière b, dubuffet t, landras c, descombes jj, simonet s, verbeuren tj, lavielle g. new tetrahydronaphthalene derivatives as combined thromboxane receptor antagonists and thromboxane synthase inhibitors. bioorg med chem lett. 1998 jun 2;8(11):1381-6.[2] rosado e, rodríguez-vilarrupla a, gracia-sancho j, tripathi d, garcía-calderó h, bosch j, garcía-pagán jc. terutroban, a tp-receptor antagonist, reduces portal pressure in cirrhotic rats. hepatology. 2013 oct;58(4):1424-35. [3] bousser mg, amarenco p, chamorro a, fisher m, ford i, fox km, hennerici mg, mattle hp, rothwell pm, de cordoüe a, fratacci md; perform study investigators. terutroban versus aspirin in patients with cerebral ischaemic events (perform): a randomised, double-blind, parallel-group trial. lancet. 2011 jun 11;377(9782):2013-22.
Check Digit Verification of cas no
The CAS Registry Mumber 165538-40-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,5,5,3 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 165538-40:
(8*1)+(7*6)+(6*5)+(5*5)+(4*3)+(3*8)+(2*4)+(1*0)=149
149 % 10 = 9
So 165538-40-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H22ClNO4S/c1-13-2-3-14-12-16(6-9-19(14)18(13)10-11-20(23)24)22-27(25,26)17-7-4-15(21)5-8-17/h2-5,7-8,16,22H,6,9-12H2,1H3,(H,23,24)/t16-/m1/s1
