165544-22-9Relevant academic research and scientific papers
MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF
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Paragraph 00296; 00297; 00298, (2018/11/22)
The present invention provides compounds, compositions thereof, and methods of using the same.
MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF
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Paragraph 0405, (2017/05/15)
The present invention provides compounds, compositions thereof, and methods of using the same.
QUINOLINE EZH2 INHIBITORS
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Page/Page column 74-75, (2017/03/08)
The present invention relates to quinolines of general formula (I) to methods for their preparation, to intermediates for their preparation, to pharmaceutical compositions comprising at least one of those compounds, and to the use thereof.
A novel method for the preparation of α,α′ -difluoroesters and acids using BrF3
Hagooly, Aviv,Sasson, Revital,Rozen, Shlomo
, p. 8287 - 8289 (2007/10/03)
Alkyl-, haloalkyl-, and ketoalkyl-2-ethoxycarbonyl-1,3-dithianes were easily made from the appropriate primary or secondary alkyl bromides, 1,3-dithiane, and ethyl chloroformate. They were reacted with BrF3 to form the corresponding α,α-difluor
Fluorination of 2-oxo-ethane derivatives with diethylaminosulfur trifluoride (DAST)
Haegele, Gerhard,Haas, Andreas
, p. 15 - 19 (2007/10/03)
The fluorination of 2-oxo-ethane derivatives with DAST is described. The use of Znl2 as a catalyst improves the yield in the fluorination of 2-phenyl-2-oxo-acetonitrile with DAST.
Conversion of α-keto esters into β,β-difluoro-α-keto esters and corresponding acids: A simple route to a novel class of serine protease inhibitors
Parisi,Gattuso,Notti,Raymo,Abeles
, p. 5174 - 5179 (2007/10/02)
The preparation of a series of β,β-difluoro-α-keto esters and corresponding acids RCF2COCO2R' (R=Me, Et, i-Pr, Bn, and Ph; R'=Et and H), designed as potential inhibitors of serine proteases, is described. The standard procedure developed consists in the initial formation of an α,α- difluoro ester from an α-keto ester, followed by a simple four-step sequence involving the synthesis of hemiacetal, cyanohydrin, and α-hydroxy ester difluorinated intermediates. This method provides an easy route to β,β- difluoro-α-keto esters and corresponding acids, via 'formal' insertion of a difluoromethylene group between the R substituent and the α-carbonyl group of a generic α-keto ester.
