165556-98-9Relevant academic research and scientific papers
Synthesis of a Novel Analogue of Sialyl Lewis X
Prodger, Jeremy C.,Bamford, Mark J.,Gore, Paul M.,Holmes, Duncan S.,Saez, Victoria,Ward, Peter
, p. 2339 - 2342 (1995)
Two different strategies have been developed in order to synthesise an analogue and potential mimic of sialyl Lewis X that incorporates a carboxymethyl group and a C2-symmetric 2,3-butanediol unit as replacements for the sialic acid and the N-acetylglucosamine residues respectively.
Mimics of the sialyl Lewis X tetrasaccharide. Replacement of the N- acetylglucosamine sugar with simple C2-symmetric 1,2-diols
Prodger,Bamford,Bird,Gore,Holmes,Priest,Saez
, p. 793 - 801 (2007/10/03)
Analogues of sialyl Lewis X have been synthesized that feature replacement of the N-acetylglucosamine residue with C2-symmetric diols. The diols used contain different levels of torsional constraint and various functional groups. The cyclohexyl derived compound 27 was equipotent to sLex in vitro (IC50 0.5 mM).
