165557-48-2Relevant academic research and scientific papers
Synthesis of (R)- or (S)-diphenylphosphinoyl hydroxy aldehydes and 1,2-diols using Mukaiyama's bicyclic aminal methodology and Sharpless asymmetric dihydroxylation
O'Brien, Peter,Warren, Stuart
, p. 2129 - 2138 (2007/10/03)
Two different approaches to diphenylphosphinoyl hydroxy aldehydes and 1,2-diols are compared. A lengthy chiral auxiliary approach using proline-derived aminals enables hydroxy aldehydes and 1,2-diols of known absolute stereochemistry and high enantiomeric
Stereocontrolled Synthesis of R or S Diphenylphosphinoyl Hydroxy Aldehydes and 1,2-Diols Using Bicyclic Aminals
O'Brien, Peter,Warren, Stuart
, p. 2681 - 2684 (2007/10/02)
Homochiral diphenylphosphinoyl hydroxy aldehydes 1 and 2 have been made by diastereoselective additions of metallated methyldiphenylphosphine oxides 10 to Mukaiyama's keto aminals 8 and 9.Reduction to diphenylphosphinoyl 1,2 diols 3 and 4 is also described.Sharpless asymmetric dihydroxylation provides an alternative route diphenylphosphinoyl 1,2 diols 3 and 4, the two approaches are compared.
