165619-85-2Relevant articles and documents
METHOD FOR PRODUCING QUINOLONE CARBOXYLIC ACID DERIVATIVE
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Page/Page column 12, (2009/12/24)
The present invention relates to a method for producing a quinolone compound having high antibacterial activity and high safety, at high yield and in a simple manner. A quinolonecarboxylic acid derivative (1) of interest is produced through a one-pot manner by reacting a compound (2) with a salt of a cyclic amine (3) and with a boron derivative in a solvent in the presence of a base.
Novel quinolonecarboxylic acid derivatives
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, (2008/06/13)
Novel compounds of the present invention are represented by the general formula (1) STR1 wherein R1 is hydrogen atom or amino, R2 is fluorine atom or methoxy, R3 is hydrogen atom or a lower alkyl having 1 to 3 carbon atoms, and n is 0 or 1. The compounds of the general formula (1) exhibit higher antibacterial activity with fewer side-effects than known quinolone antibiotics such as ofloxacin and norfloxacin. Further, the compounds having the general formula (1) have reduced phototoxicity which normally accompanies 6,8-defluoroquinoline antibiotics.