165677-45-2Relevant academic research and scientific papers
The chemistry of lithiated phosphine oxides: The stereoselective syntheses of alkene-4,5-diols
Boesen, Thomas,Feeder, Neil,Eastgate, Martin D.,Fox, David J.,Medlock, Jonathan A.,Tyzack, Charles R.,Warren, Stuart
, p. 118 - 126 (2007/10/03)
The synthesis of single enantiomers of (E)-1,5-diarylpentene-4,5-diols by elimination reaction was discussed. The stereochemistry was controlled by an asymmetric dihydroxylation, and a stereoselective reduction of a β-keto phosphine oxide. Results showed
Asymmetric dihydroxylation of allylic phosphine oxides
Nelson, Adam,Warren, Stuart
, p. 2645 - 2657 (2007/10/03)
Diphenylphosphinoyl diols have been produced by asymmetric dihydroxylation (AD) of allylic phosphine oxides and have been shown to be useful synthetic intermediates. The results of this study are discussed in terms of the model which has been proposed by Sharpless to explain the enantioselectivity of his AD reaction. The dihydroxylation results are thus of both mechanistic and synthetic value.
