165683-91-0

Upstream product

• 121745-64-0 (2R,3S)-3-azido-3-phenylpropane-1,2-diol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5817-02-7 (1S,2S)-2-amino-1-phenyl-1,3-propanediol 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 203806-61-5 (2R,3S)-3-tert-Butoxycarbonylamino-3-phenyl-2-triisopropylsilanyloxy-propionic acid methyl ester 
• 172213-23-9 (3R,4S)-1-benzoyl-3-triisopropylsilyloxy-4-phenylazetidin-2-one 
• 165683-86-3 (1S,2S)-N-tert-butoxycarbonylamino-3-tert-butyldimethylsilyloxy-2-mesyloxo-1-phenyl-1-propylamine 
• 258335-83-0 tert-butyl N-[(1S,2R)-2,3-dihydroxy-1-phenylpropyl]carbamate 

Downstream Products

• 174787-60-1 (4S,5S)-5-ethenyl-4-phenyl-1,3-oxazolidin-2-one 
• 203806-67-1 (4S,5S)-5-But-3-enyl-2,2-dimethyl-4-phenyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 259747-99-4 (1S,2S)-N-tert-butoxycarbonyl-1-phenyl-2-acetyloxy-1-butylamine 

Relevant academic research and scientific papers

Synthesis of the Neurokinin 1 Receptor Antagonist (+)-L-733,060 by Jacobsen’s Hydrolytic Kinetic Resolution

Abstract: Enantioselective synthesis of the neurokinin 1 receptor antagonist (+)-L-733,060 has been achieved using Jacobsen’s hydrolytic kinetic resolution strategy. Intermediate tert-butyl (2S,3S)-3-hydroxy-2-phenylpiperidine-1-carboxylate has been synthesized with an overall yield of 10.25% and more than 98% ee via sequential reactions starting from cinnamyl alcohol and using Grubbs metathesis in the final stage.

Stereocontrolled synthesis of all four stereoisomers of fully protected 2-amino-3-hydroxypentanoic acid from imines derived from D-glyceraldehyde

N-Benzylimines derived from conveniently protected (R)-glyceraldehyde underwent diastereoselective phenylmagnesium bromide addition to afford the corresponding aminodiols, whose absolute configuration at the newly formed stereogenic carbon depends on the

New approaches to the asymmetric synthesis of dipeptide isosteres via β-Lactam Synthon Method

New and efficient synthetic routes to dipeptide isosteres with high enantiomeric purity, e.g., hydroxyethylene, dihydroxyethylene and hydroxyethylamine isosteres, have been developed via oxiranes 6 and formyloxazolines 13 derived from N-t-Boc-β-lactams 4.

A convenient, stereodivergent approach to the enantioselective synthesis of N-Boc-aminoalkyl epoxides

An efficient, stereodivergent and enantioselective synthesis of N-Boc-aminoalkyl epoxides has been developed. Starting from enantiomerically enriched anti N-diphenylmethyl-3-amino-1,2-diols, and after a change in the nitrogen protecting group, an intramol