16571-73-6

Basic information

• Product Name: 1-<2-(4-pyridyl)ethyl>benzimidazole
• Synonyms: 1-<2-(4-pyridyl)ethyl>benzimidazole
• CAS NO: 16571-73-6
• Molecular Weight: 223.277
• Mol File: 16571-73-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-<2-(4-pyridyl)ethyl>benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-<2-(4-pyridyl)ethyl>benzimidazole(16571-73-6)
• EPA Substance Registry System: 1-<2-(4-pyridyl)ethyl>benzimidazole(16571-73-6)

Safety Data

• Hazardous Substances Data: 16571-73-6(Hazardous Substances Data)

Upstream product

• 100-43-6 4-vinylpyridine 
• 51-17-2 benzoimidazole 

Relevant articles and documents

ACIDIC PROPERTIES OF BENZIMIDAZOLES AND SUBSTITUENT EFFECTS. V. PROTECTION OF BENZIMIDAZOLES BY N-ALKYL BOND FORMATION USING VINYLPYRIDINES

Vinylpyridines were utilized for protection of the benzimidazole N-H bond to give 1-(2-pyridylethyl)-benzimidazoles.The reaction was found to progress smoothly when glacial acetic acid was used as a catalyst.In the alkylation of 5- or 7-substituted-2-arylbenzimidazoles with vinylpyridines, the yield decreased with increasing electron-attracting effect of the substituent groups in the benzimidazole ring.On the other hand, the removal of pyridylethyl groups by the use of aluminum chloride as a catalyst was kinetically examined; a large excess of sodium hydroxide was used for decomposition of the intermediate adduct of aluminum chloride.The rate increased somewhat when electron-releasing substituent groups were present in the benzimidazole ring. 1--2-arylbenzimidazoles were resistant to removal of their (2-pyridyl)ethyl groups. 4-Vinylpyridine can be used more efficiently as a protecting agent.Keywords: 2-pyridylbenzimidazoles; protection with vinylpyridines for imidazole; 1-(2-pyridylethyl)-benzimidazoles; substituent effect on N-alkylation of benzimidazoles; rate of removal of pyridylethyl groups by aluminum chloride catalyst