16576-27-5Relevant articles and documents
Synthesis method of 2-aroyl quinoline derivative
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Paragraph 0018, (2021/11/19)
The invention relates to a synthesis method of a 2-aroyl quinoline derivative, which comprises the following steps: by taking 2-bromoaniline and aryl cyclobutanol as reaction substrates, palladium chloride as a catalyst, tricyclohexylphosphine as a ligand, cesium carbonate as alkali and ultra-dry toluene as a solvent, stirring and reacting for 12 hours under the protection of nitrogen at 110 DEG C, then taking tetrabutylammonium iodide as a phase transfer catalyst, under the conditions of acetic acid and potassium persulfate, stirring and reacting for 16 hours at 90 DEG C by taking methylbenzene as a solvent; the method has the advantages of relatively low requirements on reaction conditions, mild conditions, simple operation steps, simple and easily available raw materials, great reduction of environmental pollution and the like.
Room Temperature Metal-Catalyzed Oxidative Acylation of Electron-Deficient Heteroarenes with Alkynes, Its Mechanism, and Application Studies
Sharma, Shweta,Kumar, Mukesh,Vishwakarma, Ram A.,Verma, Mahendra K.,Singh, Parvinder Pal
, p. 12420 - 12431 (2018/10/20)
Herein, we report an original one-step, simple, room-temperature, regioselective Minisci reaction for the acylation of electron-deficient heteroarenes with alkynes. The method has broad functional group compatibility and gives exclusively monoacylated products in good to excellent yields. The mechanistic pathway was analyzed based on a series of experiments confirming the involvement of a radical pathway. The 18O-labeling experiment suggested that water is a source of oxygen in the acylated product, and head space GC-MS experiment shows the C-C cleavage occurs via release as CO2.
Regiospecific benzoylation of electron-deficient n -heterocycles with methylbenzenes via a minisci-type reaction
Ali, Wajid,Behera, Ahalya,Guin, Srimanta,Patel, Bhisma K.
, p. 5625 - 5632 (2015/06/16)
A regioselective cross-dehydrogenative coupling between electron-deficient N-heterocycles (isoquinoline, quinolines, and quinoxalines) and methylbenzenes leading to regiospecific C-aroylation has been accomplished using AlCl3 as the catalyst in
