1658-42-0

Basic information

• Product Name: METHYL 2-PYRIDYLACETATE
• Synonyms: Methyl 2-pyridylacetate,98%;methyl 2-(pyridin-2-yl)acetate;Pyridin-2-yl-aceticacidMethylester;Methyl pyridine-2-acetate;Methyl 2-Pyridineacetate 2-Pyridineacetic Acid Methyl Ester 2-Pyridylacetic Acid Methyl Ester;NSC 72093;2-PYRIDINEACETIC ACID METHYL ESTER;2-PYRIDYLACETIC ACID METHYL ESTER
• CAS NO: 1658-42-0
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16
• EINECS: 216-759-8
• Product Categories: Building Blocks;C8;Chemical Synthesis;Heterocyclic Building Blocks;Heterocyclic Compounds;pyridine;C7 and C8;Heterocyclic Building Blocks;Pyridines
• Mol File: 1658-42-0.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 103 °C0.5 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear yellow liquid
• Density: 1.119 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000996mmHg at 25°C
• Refractive Index: n20/D 1.506(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.35±0.12(Predicted)
• CAS DataBase Reference: METHYL 2-PYRIDYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-PYRIDYLACETATE(1658-42-0)
• EPA Substance Registry System: METHYL 2-PYRIDYLACETATE(1658-42-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 1658-42-0(Hazardous Substances Data)

Usage

Chemical Properties

Clear yellow liquid

InChI:InChI=1/C8H9NO2/c1-11-8(10)6-7-4-2-3-5-9-7/h2-5H,6H2,1H3

Upstream product

• 67-56-1 methanol 
• 16179-97-8 pyridin-2-yl acetic acid hydrochloride 
• 1620-53-7 1-phenyl-2-pyridin-2-ylethanone 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 201230-82-2 carbon monoxide 
• 20093-35-0 methyl 3-phenyl-2-(pyridin-2-yl)acrylate 
• 2739-97-1 pyridine-2-acetonitrile 
• 6959-47-3 2-chloromethylpyridine hydrochloride 
• 586-98-1 2-Hydroxymethylpyridine 
• 109-06-8 α-picoline 
• 79-22-1 methyl chloroformate 
• 13115-43-0 2-pyridineacetic acid 
• 694-59-7 pyridine N-oxide 
• 77086-38-5 ketene t-butyldimethylsilyl methyl acetal 

Downstream Products

• 97188-60-8 [5-Phenyl-[1,2]dithiol-(3E)-ylidene]-pyridin-2-yl-acetic acid methyl ester 
• 81165-74-4 N-<2-(3,4-dimethoxyphenyl)ethyl>-2-pyridylacetamide 
• 97188-61-9 [4,5-Diphenyl-[1,2]dithiol-(3E)-ylidene]-pyridin-2-yl-acetic acid methyl ester 
• 81698-17-1 2-Methoxy-2-[1-phenyl-1H-benzo[c]isothiazol-(3E)-ylidene]-1-pyridin-2-yl-ethanone 
• 81698-16-0 [1-Phenyl-1H-benzo[c]isothiazol-(3Z)-ylidene]-pyridin-2-yl-acetic acid methyl ester 
• 120455-83-6 methyl 2-pyridyl(2-nitrophenyl)acetate 
• 118183-57-6 benzyl 2-(pyridin-2-yl)acetate 
• 17891-06-4 4-oxo-6,7,8,9-tetrahydro-4H-quinolizine-1-carboxylic acid methyl ester 
• 68888-19-7 6-(hydroxymethyl-ethyl)pyridine 
• 194228-34-7 (R)-2-(pyridin-2-yl)propan-1-ol 
• 947381-33-1 methyl 3-phenylindolizine-1-carboxylate 
• 17281-79-7 3-benzoyl-1-indolizinecarboxylic acid methyl ester 
• 274-59-9 triazolopyridine 

Relevant articles and documents

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A One-Pot Sonogashira Coupling and Annulation Reaction: An Efficient Route toward 4 H -Quinolizin-4-ones

An efficient one-pot Sonogashira coupling and annulation reaction affording 4 H -quinolizin-4-ones in moderate to excellent yields is described. A variety of substituted iodoarenes and 2-alkylazaarenes were well tolerated, and especially the unsaturated double and triple bonds were compatible under the standard conditions.

CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE

The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.