165806-69-9Relevant academic research and scientific papers
Isonitrile intermediates for the preparation of tri-substituted imidazole compounds with multiple therapeutic properties
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Page 30, (2010/01/31)
The invention relates to a novel group of isonitrile compounds and a process for their preparation, useful in the preparation of tri-substituted imadazoles having multiple therapeutic properties.
Imine intermediates for the preparation of trisubstituted imidazole compounds with multiple therapeutic properties
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Page 30, (2010/01/31)
The invention relates to a novel group of iminc compounds and a process for their preparation, useful in the preparation of tri-substituted imadazoles having multiple therapeutic properties.
Formamide intermediates for the preparation of tri-substituted imidazole compounds with multiple therapeutic properties
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Page 30, (2010/02/05)
The invention relates to a novel group of formamide compounds and a process for their preparation, useful in the preparation of tri-substituted imadazoles having multiple therapeutic properties.
Pyrimidinylimidazole inhibitors of CSBP/P38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes
Adams, Jerry L.,Boehm, Jeffrey C.,Kassis, Shouki,Gorycki, Peter D.,Webb, Edward F.,Hall, Ralph,Sorenson, Margaret,Lee, John C.,Ayrton, Andrew,Griswold, Don E.,Gallagher, Timothy F.
, p. 3111 - 3116 (2007/10/03)
Pyrimidine analogs of the pyridinylimidazole class of CSBP/p38 kinase inhibitors were prepared in an effort to reduce the potent inhibition of hepatic cytochrome P450 observed for the pyridinyl compounds. The substitution of pyrimidin-4-yl, 2-methoxypyrimidin-4-yl, or 2- methylaminopyrimidin-4-yl for pyridin-4-yl effectively dissociates CSBP/p38 kinase from P450 inhibition for this series and furthermore achieves an increase in oral activity.
Imidazole compounds, use and process of making
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, (2008/06/13)
Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
Pyridyl imidazole compounds and compositions
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, (2008/06/13)
Novel 1, 4, 5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
