1658500-48-1

Basic information

• Product Name: tert-butyl (2,6-dichloro-3-((((1r,4r)-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate
• Synonyms: tert-butyl (2,6-dichloro-3-((((1r,4r)-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate;tert-butyl (2,6-dichloro-3-(((trans-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate
• CAS NO: 1658500-48-1
• Molecular Formula: C₁₈H₂₇Cl₂N₃O₂
• Molecular Weight: 388.33188
• Mol File: 1658500-48-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 471.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.223±0.06 g/cm3(Predicted)
• PKA: 10.96±0.70(Predicted)
• CAS DataBase Reference: tert-butyl (2,6-dichloro-3-((((1r,4r)-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2,6-dichloro-3-((((1r,4r)-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate(1658500-48-1)
• EPA Substance Registry System: tert-butyl (2,6-dichloro-3-((((1r,4r)-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate(1658500-48-1)

Safety Data

• Hazardous Substances Data: 1658500-48-1(Hazardous Substances Data)

Upstream product

• 2897-43-0 2,6-dichloro-3-nitropyridin-4-amine 
• 1313726-52-1 tert-butyl (2,6-dichloro-3-nitropyridin-4-yl)carbamate 
• 7133-05-3 trans-4-(methyl)cyclohexane-1-carbaldehyde 
• 1616434-23-1 tert-butyl (3-amino-2,6-dichloropyridin-4-yl)carbamate 
• 94-60-0 dimethyl 1,4-cyclohexane dicarboxylate 
• 2587-02-2 2,6-dichloro-[4]pyridylamine 
• 2587-03-3 2,6-dichloro-N-nitro-4-pyridinamine 
• 3937-49-3 (trans-4-methylcyclohexyl)methanol 
• 170811-08-2 trans-4-(hydroxymethyl)cyclohexylmethyl 4-methylbenzenesulfonate 
• 3236-48-4 trans-1,4-Cyclohexanedimethanol 

Downstream Products

• 1658500-49-2 2,6-dichloro-N³-((trans-4-methylcyclohexyl)methyl)pyridine-3,4-diamine 
• 1616434-24-2 4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine 
• 1616434-25-3 2-bromo-4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine 
• 1616434-26-4 4,6-dichloro-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3-phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridine 
• 1616434-27-5 6-chloro-4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3-phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridine 
• 1616434-28-6 4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3-phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridine-6-carbonitrile 
• 1616428-74-0 5-{4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3-phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridin-6-yl}-1,3,4-oxadiazol-2(3H)-one 
• 1616431-67-4 methyl 4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3-phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridine-6-carboxylate 
• 1658500-51-6 4-(5-chloropyridin-3-yl)-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3-phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridine-6-carbohydrazide 
• 1616434-31-1 2-bromo-4-(5-chloropyridin-3-yl)-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile 
• 1616434-29-7 6-chloro-4-(5-chloropyridin-3-yl)-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine 
• 1616434-30-0 4-(5-chloropyridin-3-yl)-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine-6-carbonitrile 
• 1616428-78-4 3-(4-(5-chloropyridin-3-yl)-2-((S)-2-(fluoromethyl)pyrrolidin-1-yl)-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridin-6-yl)-1,2,4-oxadiazol-5(4H)-one 
• 1616434-97-9 4-(5-chloropyridin-3-yl)-2-[(2S)-2-(fluoromethyl)pyrrolidin-1-yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridine-6-carbonitrile 

Relevant articles and documents

Substituted Imidazopyridines as HDM2 Inhibitors

The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.