165960-98-5

Upstream product

• 165960-97-4 ((R)-10-Methoxymethoxy-tridec-12-enyloxymethyl)-benzene 

Downstream Products

• 1026914-62-4 Benzoic acid (S)-4-{(2R,13R)-2,13-bis-methoxymethoxy-13-[(2R,5R,2'R,5'R)-5'-((S)-1-methoxymethoxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-tridecyl}-2-methyl-5-oxo-tetrahydro-furan-3-yl ester 
• 1026813-71-7 Benzoic acid (S)-4-{(2R,13S)-2,13-bis-methoxymethoxy-13-[(2R,5R,2'R,5'R)-5'-((R)-1-methoxymethoxy-undecyl)-octahydro-[2,2']bifuranyl-5-yl]-tridecyl}-2-methyl-5-oxo-tetrahydro-furan-3-yl ester 
• 165961-06-8 Toluene-4-sulfonic acid (S)-2-{(2R,5R,2'R,5'R)-5'-[(1R,12R)-15-(tert-butyl-dimethyl-silanyloxy)-1-hydroxy-12-methoxymethoxy-pentadecyl]-octahydro-[2,2']bifuranyl-5-yl}-2-hydroxy-ethyl ester 
• 165961-01-3 Toluene-4-sulfonic acid (R)-13-(tert-butyl-dimethyl-silanyloxy)-10-methoxymethoxy-tridecyl ester 
• 165961-03-5 ((R)-13-Benzenesulfonyl-4-methoxymethoxy-tridecyloxy)-tert-butyl-dimethyl-silane 
• 165961-02-4 tert-Butyl-((R)-4-methoxymethoxy-13-phenylsulfanyl-tridecyloxy)-dimethyl-silane 
• 165960-99-6 (+)-(4R)-13-(Benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-4-<(methoxymethyl)oxy>tridecane 

Relevant academic research and scientific papers

The First Total Synthesis of (+)-Bullatacin, a Potent Antitumor Annonaceous Acetogenin, and (+)-(15,24)-bisepi-Bullatacin

This paper reports the first total synthesis of the natural product (+)-bullatacin (1), a representative of potent antitumor Annonaceous acetogenins, as well as a stereoisomer (+)-(15,24)-bisepi-bullatacin (2).In this synthesis, a new, efficient method has been developed to introduce the γ-lactone into the bistetrahydrofuran skeleton through in situ alkylation of epoxide 4 by the α-sulfonyl carbanion of phenylsulfone 5.The methylated γ-lactone was successfully synthesized by a sequence of reactions comprising an aldol reaction, an acidic lactonization, and elimination under mild, basic condition.