166023-29-6

Basic information

• Product Name: TERT-BUTYL (3R)-3-AMINO-5-METHYLHEXANOATE, 97
• Synonyms: TERT-BUTYL (3R)-3-AMINO-5-METHYLHEXANOATE, 97;Hexanoic acid, 3-aMino-5-Methyl-, 1,1-diMethylethyl ester, (R)-
• CAS NO: 166023-29-6
• Molecular Formula: C₁₁H₂₃NO₂
• Molecular Weight: 201.308
• Mol File: 166023-29-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 260.5 °C at 760 mmHg
• Flash Point: 122.9 °C
• Appearance: Clear colorless to yellow/Liquid
• Density: g/cm³
• Vapor Pressure: 0.0122mmHg at 25°C
• CAS DataBase Reference: TERT-BUTYL (3R)-3-AMINO-5-METHYLHEXANOATE, 97(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL (3R)-3-AMINO-5-METHYLHEXANOATE, 97(166023-29-6)
• EPA Substance Registry System: TERT-BUTYL (3R)-3-AMINO-5-METHYLHEXANOATE, 97(166023-29-6)

Safety Data

• Hazardous Substances Data: 166023-29-6(Hazardous Substances Data)

Usage

Chemical Properties

clear yellowish liquid

InChI:InChI=1/C11H23NO2/c1-8(2)6-9(12)7-10(13)14-11(3,4)5/h8-9H,6-7,12H2,1-5H3/p+1/t9-/m1/s1

Upstream product

• 1169704-25-9 C₁₅H₃₁NO₃S 
• 590-86-3 isovaleraldehyde 
• 138877-97-1 tert-butyl (E)-5-methyl-hex-2-enoate 
• 27784-76-5 tert-butyl diethylphosphonoacetate 
• 951174-29-1 tert-butyl (3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)-5-methylhexanoate 
• 138878-02-1 3-(3,5-Dihydro-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-5-methyl-hexanoic acid tert-butyl ester 

Downstream Products

• 91298-67-8 (R)-3-amino-5-methylhexanoic acid 

Relevant articles and documents

Scalable scny BRAnthesis of β-amino esters via reformatskcny BRA reaction with N-tert-butanesulfincny BRAl imines

The Reformatskcny BRA reagents derived from ethcny BRAl bromoacetate and tert-butcny BRAl bromoacetate add cleanlcny BRA, in high cny BRAield, and with good diastereoselectivitcny BRA to N-tert-butanesulfincny BRAl aldimines and ketimines. Importantlcny BRA, this reaction scales well (>50 mmol), and affords products upwards of 70% cny BRAield over three steps, starting from commerciallcny BRA available N-tert-butanesulfinamide, aldehcny BRAdes, and ketones.

An Asymmetric Ammonia Synthon for Michael Additions

The highly diastereoselective 1,4-addition of lithiated chiral amine 1 to α,β-unsaturated esters, followed by hydrogenolysis of the benzylic-type C-N bonds of the 1,4-adducts, provides an asymmetric ammonia synthon for Michael additions.Under optimized co