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166037-21-4

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166037-21-4 Usage

General Description

Cilastatin is a renal dehydropeptidase inhibitor that is commonly co-administered with the antibiotic imipenem. It works by preventing the breakdown of imipenem by renal tubular dehydropeptidase, resulting in increased and prolonged levels of imipenem in the body. This combination therapy is used to treat severe infections caused by susceptible bacteria. Cilastatin itself does not have antibiotic properties, but it enhances the activity of imipenem by protecting it from degradation in the kidneys. Common side effects of cilastatin include nausea, vomiting, diarrhea, and allergic reactions. It is typically administered intravenously in a hospital setting.

Check Digit Verification of cas no

The CAS Registry Mumber 166037-21-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,6,0,3 and 7 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 166037-21:
(8*1)+(7*6)+(6*6)+(5*0)+(4*3)+(3*7)+(2*2)+(1*1)=124
124 % 10 = 4
So 166037-21-4 is a valid CAS Registry Number.

166037-21-4Relevant articles and documents

Cilastatin sodium intermediate preparation method

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, (2020/03/09)

The invention belongs to the technical field of medicines, and particularly provides a cilastatin sodium intermediate preparation method, which comprises: simply preparing a (Z)-7-X-2((2s)-2,2-dimethylcyclopropaneformamido)-2-heptenoic acid crude product through a one-pot method by using 7-X-2-oxoheptanoic acid ethyl ester and (s)-2,2-dimethylcyclopropaneformamide as raw materials sequentially under the action of a catalyst, concentrated hydrochloric acid and hydrogen chloride gas, and re-crystallizing to prepare a (Z)-7-X-2((2s)-2,2-dimethylcyclopropaneformamido)-2-heptenoic acid refined product. According to the invention, the method has advantages of short synthetic route, simple operation and high product purity, and is suitableness for industrial production.

Purification method of ethyl 7-chloro-2-oxoheptanoate

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, (2017/01/19)

The invention provides a purification method of ethyl 7-chloro-2-oxoheptanoate, wherein the purification method comprises the steps: firstly, carrying out a reaction of ethyl 7-chloro-2-oxoheptanoate oil crude product and a hydrosulphite solution, and separating to obtain a sulfite solid of ethyl 7-chloro-2-oxoheptanoate; then, dissolving the sulfite solid of ethyl 7-chloro-2-oxoheptanoate in water, adding an acid or alkali at a certain temperature, and decomposing the sulfite of ethyl 7-chloro-2-oxoheptanoate into ethyl 7-chloro-2-oxoheptanoate; and finally, extracting with an organic solvent immiscible with water, to obtain ethyl 7-chloro-2-oxoheptanoate having the purity improved. The method is simple in operation and suitable for industrialized production, and ensures the purity of a subsequent product and final product cilastatin sodium.

An improved process for the preparation of cilastatin acid

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Page/Page column 5, (2012/02/04)

The present invention relates to an improved process for the preparation of Cilastatin Sodium of formula (I). The present invention also provides an isolation technique for Cilastatin acid from the reaction mixture.

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