16607-47-9Relevant academic research and scientific papers
PHARMACEUTICAL COMPOSITIONS AND METHODS FOR RELIEVING PAIN AND TREATING CENTRAL NERVOUS SYSTEM DISORDERS
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Page/Page column 68, (2008/06/13)
Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attention deficient disorder, or schizophrenia), are treated by administering a compound of Formulas (1 or 2), as described herein. The compounds of Formulas (1 and 2) are also useful for treating pain, and treating drug addiction, nicotine addiction, and/or obesity. The compounds can exist as individual stereoisomers, racemic mixtures, diastereomers and the like.
Synthesis and Stereoselective Reduction of (+/-)-, (+)- and (-)-6-Substituted-6-azabicyclooctan-3-one
Pitner, J. Bruce,Abraham, Philip,Joo, Young J.,Triggle, David J.,Carroll, F. Ivy
, p. 1375 - 1381 (2007/10/02)
Starting with 6-oxabicyclooct-3-en-7-one 6, a three step, general synthetic route to both racemic and optically active 6-substituted 6-azabicyclooctan-3-ones has been developed.Opening of the lactone ring of 6 with amines gave amides which w
