16611-23-7

Upstream product

• 121-73-3 3-Nitrochlorobenzene 
• 14933-91-6 N-phenyl-benzenesulphenamide 
• 62-53-3 aniline 
• 350-30-1 3-chloro-4-fluoronitrobenzene 

Downstream Products

• 95109-73-2 2-chloro-N₁-phenylbenzene-1,4-diamine 
• 1620782-78-6 2-chloro-4-isothiocyanato-N-phenylaniline 
• 1620878-51-4 (Z)-methyl N-3-chloro-4-(phenylamino)phenyl-N'-cyanocarbamimidothioate 
• 1620782-52-6 N³-(3-chloro-4-phenylaminophenyl)-1H-[1,2,4]triazole-3,5-diamine 

Relevant academic research and scientific papers

ANTIVIRAL TRIAZOLE DERIVATIVES

The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.

Nitroarylamines via the Vicarious Nucleophilic Substitution of Hydrogen: Amination, Alkylamination, and Arylamination of Nitroarenes with Sulfenamides

A new reaction of sulfenamides with electrophilic arenes under basic conditions is described. The σ adducts formed from nitroarenes and the anions of sulfenamides undergo elimination of thiol to produce the corresponding o- and/or p-nitroanilines. This reaction is analogous to the known alkylation and hydroxylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen (VNS). The reaction gives access to a wide range of substituted nitroanilines, nitronaphthylamines, and aminoheterocycles. By means of the reaction with N-alkyl- and N-arylsulfenamides, it is possible to obtain N-alkylnitroanilines and nitrodiarylamines. By varying the structure of sulfenamide and the reaction conditions, particularly the nature and concentration of the base, it is possible to control the orientation of animation.