166113-79-7Relevant articles and documents
Regioselective synthesis of 5,6-polymethylene-3-cyanopyridine-2(1H)-thiones and fused heterocycles based on them
Rodinovskaya, L. A.,Belukhina, E. V.,Shestopalov, A. M.,Litvinov, V. P.
, p. 449 - 457 (2007/10/02)
Condensation of 2-hydroxymethylenecyclopentan-1-one or -cyclooctan-1-one sodium salts with cyanothioacetamide afforded 5,6-polymethylene-3-cyanopyridine-2(1H)-thiones which were regioselectively alkylated at the sulfur atom by alkyl halides.Derivatives of 3-cyanopyridine-2(1H)-thione and 2-alkylthio-3-cyanopyridine were used for regioselective synthesis of substituted heterocycles: 3-aminothienopyridines, pyridothienopyrimidines, and pyridothienooxazines. - Key words: fused heterocycles; 5,6-polymethylene-3-cyanopyridine-2(1H)-thiones; 2-alkylthio-3-cyanopyridines; 3-aminothienopyridines; pyridothienopyridines; pyridothienooxazines; regioselective synthesis.
